Results 171 to 180 of about 11,022,196 (359)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advanced Wilms Tumor in a Middle-Aged Adult: A Case Report. [PDF]

Clin Case Rep
Mucunguzi D, Ngowi BN, Mbwambo OJ, Mwijumbe PJ, Maro NN, Mayengela A, Mwakitwange A, Amsi P, Lema DD, Mremi A.   +9 more
europepmc   +1 more source

The Use of Environmental Methods for Studying the Fortification, Economic System and Natural Environment of a Hillfort from the Beginning of the Middle Bronze Age at Vrcovice, Czech Republic

, 2014
Daniel Hlásek, Petra Houfková, Lenka Kovačíková, Antonín Majer, Jan Novák, Jaroslav Pavelka, Tomáš Bešta, Tereza Šálková, Tereza Šálková   +8 more
openalex   +1 more source

The Birth of the Three Great Islamic Kingdoms in the Middle Ages (1250-1800 AD)

, 2022
Elda Harits Fauzan, Agus Mahfudin Setiawan   +1 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Explaining middle-aged women's experiences of reproductive health care of the middle-aged program (30-59 years old) during the covid-19 epidemic. [PDF]

J Educ Health Promot
Noroozi M, Safinejad H, Mohebbi-Dehnavi Z.   +2 more
europepmc   +1 more source

A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans

The Journal of Nutrition, Health & Aging, 2012
J. Morley, T. Malmstrom, Douglas K. Miller   +2 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Group B streptococcal meningitis in a middle-aged woman

, 2007
Adam L. Holyoak, Todd A. Fraser
openalex   +1 more source

Chemotherapy Use and Survival Among Young and Middle-Aged Patients With Colon Cancer

JAMA Surgery, 2017
Janna Manjelievskaia, Derek W Brown, K. McGlynn, W. Anderson, C. Shriver, K. Zhu   +5 more
semanticscholar   +1 more source