Results 201 to 210 of about 12,195,030 (401)

Risk factors for urinary incontinence among middle-aged women [PDF]

, 2006
Kim N. Danforth, Mary K. Townsend, Karen L. Lifford, Gary C. Curhan, Neil M. Resnick, Francine Grodstein   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.

Gastroenterology, 2011
C. D. Williams, Joel Z Stengel, Michael Asike, D. Torres, J. Shaw, M. Contreras, Cristy L Landt, S. Harrison   +7 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advanced Wilms Tumor in a Middle-Aged Adult: A Case Report. [PDF]

Clin Case Rep
Mucunguzi D, Ngowi BN, Mbwambo OJ, Mwijumbe PJ, Maro NN, Mayengela A, Mwakitwange A, Amsi P, Lema DD, Mremi A.   +9 more
europepmc   +1 more source

Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults

Annals of Internal Medicine, 2017
K. Diaz, V. Howard, B. Hutto, N. Colabianchi, J. Vena, M. Safford, S. Blair, S. Hooker   +7 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma

, 2021
Oliver Djurhuus Tupper, Zorana Jovanovic Andersen, Charlotte Suppli Ulrik   +2 more
openalex   +1 more source

Chemotherapy Use and Survival Among Young and Middle-Aged Patients With Colon Cancer

JAMA Surgery, 2017
Janna Manjelievskaia, Derek W Brown, K. McGlynn, W. Anderson, C. Shriver, K. Zhu   +5 more
semanticscholar   +1 more source