Results 51 to 60 of about 10,435,023 (317)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Chemotherapy Use and Survival Among Young and Middle-Aged Patients With Colon Cancer
JAMA Surgery, 2017 Importance Treatment options for patients with young-onset colon cancer remain to be defined and their effects on prognosis are unclear. Objective To investigate receipt of adjuvant chemotherapy by age category (18-49, 50-64, and 65-75 years) and assess ...
J. Manjelievskaia +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
Clinical Epigenetics, 2017 BackgroundHuman aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an individual, thus providing a new ...
T. Nevalainen +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Understanding the Limitations of Gyrochronology for Old Field Stars [PDF]
Astrophys. J. 871, 39 (2019), 2018 Nearly half a century has passed since the initial indications that stellar rotation slows while chromospheric activity weakens with a power-law dependence on age, the so-called Skumanich relations. Subsequent characterization of the mass-dependence of this behavior up to the age of the Sun led to the advent of gyrochronology, which uses the rotation ...
arxiv +1 more source
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Modelling hippocampal neurogenesis across the lifespan in seven species [PDF]
, 2011 The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species. Data from mice (Mus musculus), rats (Rattus norvegicus), lesser hedgehog tenrecs (Echinops telfairi), macaques (Macaca mulatta), marmosets (Callithrix
arxiv +1 more source
Is happiness u-shaped in age everywhere? A methodological reconsideration for Europe [PDF]
arXiv, 2021 A recent contribution to research on age and well-being (Blanchflower 2021) found that the impact of age on happiness is "u-shaped" virtually everywhere: happiness declines towards middle age and subsequently rises, in almost all countries. This paper evaluates that finding for European countries, considering whether it is robust to alternative ...
arxiv
Circulation, 2015 Background— Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. Methods and Results— The PESA (Progression of Early Subclinical Atherosclerosis) study prospectively enrolled 4184 ...
L. Fernández-Friera +22 more
semanticscholar +1 more source