Results 61 to 70 of about 10,435,023 (317)
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Journal of Clinical Endocrinology and Metabolism, 2015 CONTEXT Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders.
J. Yu +13 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Modeling statistical properties of the X-ray emission from aged Pulsar Wind Nebulae [PDF]
, 2013 The number of known PWNe has recently increased considerably, and the majority of them are now middle-age objects. Recent studies have shown a clear correlation of both X-ray luminosity and size with the PWN age, but fail in providing a thorough explanation of the observed trends.
arxiv +1 more source
Physiological and Psychological Effects of a Forest Therapy Program on Middle-Aged Females
International Journal of Environmental Research and Public Health, 2015 The natural environment is increasingly recognized as an effective counter to urban stress, and “Forest Therapy” has recently attracted attention as a relaxation and stress management activity with demonstrated clinical efficacy.
H. Ochiai +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
XMM observations of three middle-aged pulsars [PDF]
arXiv, 2003 X-ray observations of middle-aged pulsars allow one to study nonthermal radiation from pulsar magnetospheres and thermal radiation from neutron star (NS) surfaces. In particular, from the analysis of thermal radiation one can infer the surface temperatures and radii of NSs, which is important for investigating evolution of these objects and ...
arxiv
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
International Journal of Environmental Research and Public Health, 2015 Time spent walking and relaxing in a forest environment (“forest bathing” or “forest therapy”) has well demonstrated anti-stress effects in healthy adults, but benefits for ill or at-risk populations have not been reported. The present study assessed the
H. Ochiai +10 more
semanticscholar +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source