Results 71 to 80 of about 1,533,855 (292)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Explaining the personal cognitive factors affecting physical activity and nutritional behaviors in the middle‐aged at risk of coronary artery disease: A directed qualitative content analysis

open access: yesHealth Science Reports
Background and Aims Coronary artery disease (CAD) is the most common cardiovascular disease worldwide. Nutrition and physical activity are recognized as the major lifestyle‐related behaviors to reduce the risk of noncommunicable diseases. It is essential
Roghayeh Ezati Rad   +5 more
doaj   +1 more source

The influence of middle-aged and older adults’ social capital and education on physical function: evidence from the China Health and Retirement Longitudinal Study

open access: yesFrontiers in Public Health
BackgroundPopulation aging is a major global trend with significant social, economic, and health implications. In China, the increasing aging population presents challenges, including increased chronic diseases and disabilities.
Tingfai Man   +8 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

HIV/AIDS in people aged 50 and older in the province of Las Tunas, a fifteen year study

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Background: the prevalence of infection by the human immunodeficiency virus (HIV) is increasing in the population aged over 50 years, both due to increased survival and new diagnoses.Objective: to characterize the people aged 50 years and older ...
Martha Odalis Cabrales-León   +4 more
doaj  

A Crisis in the Middle Ages [PDF]

open access: yesPapers of the American Society of Church History, 1889
Pope Gregory VII. had pronounced excommunication upon Henry IV., Emperor of Germany, and divided the German princes. The latter held a meeting, at which it was resolved that Gregory should be invited to Augsburg to hear, in an assembly of the princes, all the charges against their emperor, after which the final decision of the case should be left to ...
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

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