Results 101 to 110 of about 10,907,811 (379)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Food globalization in southern Central Asia: archaeobotany at Bukhara between antiquity and the Middle Ages. [PDF]

open access: yesArchaeol Anthropol Sci, 2023
Mir-Makhamad B   +4 more
europepmc   +1 more source

The Genesis of Science: How the Christian Middle Ages Launched the Scientific Revolution

open access: yes, 2011
The Not-So-Dark Dark Ages What they forgot to teach you in school: People in the Middle Ages did "not" think the world was flatThe Inquisition never executed "anyone" because of their scientific ideologiesIt was medieval scientific discoveries, including
J. Hannam
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

“A Mirror for Men” – Reconstructing a Medieval Polishing Bench and Putting it to the Test

open access: yesEXARC Journal, 2020
In the late 5th century AD, the famous Ostrogoth Theoderic the Great received a truly regal gift from the king of the Warini: he was given highly elaborated swords, richly decorated and able to cut through armour.
Florian Messner
doaj  

Bruno da Longobucco (da Longoburgo): The first academic surgeon in the Middle Ages. [PDF]

open access: yesFront Surg, 2022
Pata F   +5 more
europepmc   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

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