Results 161 to 170 of about 1,771,516 (307)

Author Correction: Spotted phenotypes in horses lost attractiveness in the Middle Ages. [PDF]

open access: yesSci Rep, 2020
Wutke S   +16 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

What's "Middle" About the Middle Ages? [PDF]

open access: yes
A medieval historian explains why the Dark Ages weren't dark at all and why they are fun to ...
Brown, Warren C.
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Africa’s Transitions to the Middle Ages

open access: yesMedieval Worlds, 2022
Paolo Tedesco
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

ASPECTS OF ECONOMIC LIFE IN FRANCOLISE DURING THE MIDDLE AGES [PDF]

open access: yes
Francolise is a small farm and thermal town that rises on the right bank of the river Volturno, in the territory of Calvi Risorta, in the province of Caserta. It is well known above all for its embattled castle dating back to about the thirteenth century
Giancarlo BOVA
core  

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