Results 161 to 170 of about 1,783,475 (300)

7. The Two Swords in Theory and Practice

, 1958
The claims to universality advanced by the medieval Church brought it into close relationship with an ancient human institution: the state. Especially after the fourth century, when it was first recognized and then given status as the only legal ...
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold A., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Lamentation of Jesus

, 2017
The lamentation of Jesus is one of the important biblical-artistic themes around Jesus’ death and resurrection since the Middle Ages – including themes such as the crucifixion, deposition, pietà, anointing, and entombment (see above “I.
Yang, Sunggu
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Advancing back to the Middle Ages: the barbers of Saxmundham. [PDF]

Br J Gen Pract
Havard J.
europepmc   +1 more source

Cause-specific contributions to sex differences in adult mortality among whites and African Americans between 1960 and 1995 [PDF]

The purpose of this paper is to describe trends in sex differences in mortality in young adulthood and in middle age among African Americans and whites in the United States between 1960 and 1995.
Greg L. Drevenstedt, Irma Elo
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Evolution of the Asian summer monsoon and regional karst ecological environment since the middle ages in Southwest China. [PDF]

Sci Rep
Wang CY, Li JY, Chen CJ, Zhang J, Wu Y, Cheng H, Shen CC, Li TY.   +7 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Africa’s Transitions to the Middle Ages

Medieval Worlds, 2022
Paolo Tedesco
doaj   +1 more source