Results 41 to 50 of about 476,712 (311)

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

POST-PRESENT MIDDLE AGES AND GLOBAL TRANSFORMATIONS

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2013
Purpose To investigate globalization as the socio-cultural phenomenon of dichotomizing property and on this basis to prove medieval analogies in prospects of modern societies development.
Savtchenko Irina Aleksandrovna
doaj   +2 more sources

Volhynian Provenance of the Radziwill Chronicle: Hypothesis and Its Critical Assessment

open access: yesКиївські історичні студії
The Radziwill chronicle is a unique Cyrillic manuscript dating back to the late 15th century. It was named after Radziwill princely family who kept it in the mid-17th century.
Olena Rusyna
doaj   +1 more source

Rodin, Vigeland and the Middle Ages

open access: yesKunst og Kultur, 2020
In his search for an effective form for his famous Burghers of Calais (1884–1895), Auguste Rodin seems to have looked at medieval models. The emotional expressiveness of medieval sculpture also inspired Gustav Vigeland who refers in his early works to ...
Marthje Sagewitz
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The Provenance of the Radziwill Chronicle

open access: yesКиївські історичні студії
The Radziwill chronicle is a unique illuminated Cyrillic manuscript of the late 15th century. Its miniatures cover historical period from the mythical beginnings of Rus’ up to the early 13th century.
Olena Rusyna
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Exploitation d’arbustes aux périodes romaine et médiévale. Branchages des puits de Marne-La-Vallée

open access: yesArchéopages, 2012
The quantity of branches recovered in preventive excavations at Marne-la-Vallée warrants a summary and synthesis of the results of their study. For practical reasons, three different wood specialists have examined assemblages that were close in time and ...
Julien Dez   +2 more
doaj   +1 more source

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