Results 81 to 90 of about 11,148,453 (358)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

India Traders of the Middle Ages

open access: yesAmerican Journal of Islam and Society, 2009
Throughout Antiquity, the Middle Ages, and our current era, the Indian Ocean has been the economic backbone of an interconnected global community. This inter-territorial commerce, which feeds a vast network of merchants from the western Mediterranean to ...
Isa Blumi
doaj   +1 more source

6. The Church in the Economic Sphere

open access: yes, 1958
Since the Church in the Middle Ages claimed to teach in all its fulness every doctrine that men ought to be brought to know, it was obligated to enunciate and propagate a set of definite principles for guiding medieval men as, in one way or another ...
Bloom, Robert L.   +6 more
core  

Surgical education in the middle ages [PDF]

open access: yes, 2000
The new surgical texts of the thirteenth century suggest that their authors wished their subject to appear as a learned discipline, yet it was still communicated by individual practitioners privately to one or two disciples, not in a university setting ...
Mc Vaugh, Michael
core   +2 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

La frontière dans les généalogies du Libro Verde de Aragón

open access: yesLes Cahiers de Framespa, 2015
The three thousand characters of Libro Verde de Aragón –a genealogical collection describing the descendants of Aragonese Jews converted around 1400– had good reasons of crossing the borders of kingdom of Aragon.
Monique Combescure Thiry   +1 more
doaj   +1 more source

8. The Gothic Cathedral

open access: yes, 1958
The Gothic cathedral, like the Summa of Aquinas, the University of Paris, and the Christendom of Innocent III, stands as one of the major expressions of the spirit of the High Middle Ages.
Bloom, Robert L.   +6 more
core  

‘Turning many to righteousness’ : Religious didacticism in the ›Speculum humanae salvationis‹ and the similitude of the oak tree [PDF]

open access: yes, 2011
In this contribution I shall be interested, among other things, in finding a place for the European phenomenon of the ›Speculum humanae salvationis‹ within German literary history, which will inescapably involve revisiting the unfashionable discussion of
Palmer, Nigel F.
core  

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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