Results 181 to 190 of about 471,464 (304)

Integrating multi-atlas neuroimaging data for robust biomarker identification in neuropsychiatric disorders. [PDF]

Front Psychiatry
Zhou L, Liu Y, Wang K, Wang X, He M, Zhu H, Zhang J.   +6 more
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Mapping Human Corpus Callosum Connectivity With Diffusion Spectrum Imaging: A Deterministic Tractography Approach. [PDF]

Brain Behav
Zhang C, Shi JW, Wang ZM, Wei PH, Lu C, Wang YH, Zhang HQ, Fan XT, Shan YZ, Lu J, Ou SQ, Zhao GG.   +11 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Development of a comprehensive GWAS atlas for chicken breeds. [PDF]

BMC Bioinformatics
Al-Anzi BF, Alkhalifah NB, Almansouri HA, AlSirhan A.   +3 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Delineating In Vivo T1-Weighted Intensity Profiles Within the Human Insula Cortex Using 7-Tesla MRI. [PDF]

Hum Brain Mapp
Dalby C, Dibble A, Carvalheiro J, Queirazza F, Sevegnani M, Harvey M, Svanera M, Fracasso A.   +7 more
europepmc   +1 more source

Review of Student Atlas of Oregon: A Classroom Atlas for Elementary and Middle Schools

Cartographic Perspectives, 2011
openaire   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Inclusion bias affects common variant discovery and replication in a health-system linked biobank. [PDF]

Am J Hum Genet
Pimplaskar A, Qiu J, Lapinska S, Tozzo V, Chiang JN, Pasaniuc B, Olde Loohuis LM.   +6 more
europepmc   +1 more source