Results 231 to 240 of about 471,464 (304)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Assessing the Performance of BioEmu in Understanding Protein Dynamics. [PDF]

Int J Mol Sci
Zha J, Li N, Li M, Liu X, Zhu R, Feng L, Lu X, Zhang J.   +7 more
europepmc   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

Advanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina, Kanghwan Kim, Wesley Charles Smith, Keuntae Kim, Shinwoo Lee, Jiwan Woo, Il‐Joo Cho   +6 more
wiley   +1 more source

Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas. [PDF]

Sci Rep
Manjón JV, Morell-Ortega S, Ruiz-Perez M, Mansencal B, Bot EL, Gadea M, Lanuza E, Catheline G, Tourdias T, Planche V, Giraud R, Rivière D, Mangin JF, Labra-Avila N, Vivo-Hernando R, Rubio G, Aparici-Robles F, de la Iglesia-Vaya M, Coupé P.   +18 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Cortical Structure Alterations in Young People With Mild Internet Gaming Disorder. [PDF]

Addict Biol
Mei B, Ma L, Tao Q, Dang J, Sun J, Zhang M, Cheng J, Zhang Y.   +7 more
europepmc   +1 more source

Lung cancer risk in relation to indicative radon atlas metrics in Northern Ireland: a population-based case-control study using secondary data. [PDF]

Environ Geochem Health
Delargy CM, Coleman HG, Crowley QG, Bennett D, Elio J, Fitzpatrick D, Mitchell H, Wallace SM, Alhattab RAN, Scott A, McGuinness B, Hunter RF, McKay GJ, Middleton DRS.   +13 more
europepmc   +1 more source

Temporal gating of sex-specific apoptosis shapes the sexually dimorphic brain. [PDF]

Cell Genom
Hopkins BR, Kopp A.
europepmc   +1 more source

A large scale multi-dataset investigation of brain metastases distribution based on primary cancer type. [PDF]

BMC Cancer
Lyu Q, Yuan H, Lin Z, Barcus R, Hudson J, Jiang Y, Kim J, Whitlow CT.   +7 more
europepmc   +1 more source