Results 121 to 130 of about 619,798 (346)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Author Correction: A Tunguska sized airburst destroyed Tall el-Hammam a Middle Bronze Age city in the Jordan Valley near the Dead Sea. [PDF]

Sci Rep, 2023
Bunch TE, LeCompte MA, Adedeji AV, Wittke JH, Burleigh TD, Hermes RE, Mooney C, Batchelor D, Wolbach WS, Kathan J, Kletetschka G, Patterson MCL, Swindel EC, Witwer T, Howard GA, Mitra S, Moore CR, Langworthy K, Kennett JP, West A, Silvia PJ.   +20 more
europepmc   +1 more source

Vegetation history and climatic fluctuations on a transect along the Dead Sea west shore and impact on past societies over the last 3500 years. [PDF]

, 2010
This study represents the vegetation history of the last 3500 years and conducts an analysis of the climatic fluctuations on a 75 km long transect on the western Dead Sea shore.
Al-Eisawi, Baruch, Baruch, Baruch, Behre, Beit-Arieh, Ben Moshe, Ben-Itzhak, Bitan, Bookman, Bookman (Ken-Tor), Brun, Danin, Danin, Danin, Dayan, Dever, E.J. Kagan, El-Naqa, Enzel, F.H. Neumann, Feinbrun-Dothan, Finkelstein, Finkelstein, Freund, Frumkin, Frumkin, Frumkin, Garfunkel, Gavrieli, Hecht, Heim, Horowitz, Issar, Jaffe, Klein, Klinger, Lamb, Migowski, Miller Rosen, Neev, Neev, Neumann, Nissenbaum, Náaman, Néeman, Rabinowitch-Vin, Rosen, Rubin, S.A.G. Leroy, Singer, Stein, Stiller, Stuiver, U. Baruch, Walter, Weiss, Yakir, Yechieli, Zohary   +59 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Technological insights on the Early-Middle Bronze Age pottery of Monte Meana cave (Sardinia, Italy). [PDF]

Heliyon, 2022
Paglietti G, Tanda G, Melis RT, Musinu A, Cruciani G, Franceschelli M, Cannas C, Mameli V, Casu M.   +8 more
europepmc   +1 more source

Transformations in the Carpathian Basin around 1600 B. C. [PDF]

, 2013
Um die Zeit des Vulkanausbruchs von Thera fanden wichtige Veränderungen im Karpatenbecken statt. Diese sogenannte Koszider Epoche korrespondiert mit der letzten Phase der mittleren Bronzezeit in der ungarischen Terminologie und stellt den Übergang ...
Fischl, Klára P., Kiss, Viktória, Kulcsár, Gabriella, Szeverényi, Vajk   +3 more
core  

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Sidon on the breadth of the wild sea: Movement and diet on the Mediterranean coast in the Middle Bronze Age. [PDF]

Am J Biol Anthropol, 2022
Stantis C, Maaranen N, Kharobi A, Nowell GM, Macpherson C, Doumet-Serhal C, Schutkowski H.   +6 more
europepmc   +1 more source

Ancient harbour infrastructure in the Levant: tracking the birth and rise of new forms of anthropogenic pressure

, 2014
Beirut, Sidon and Tyre were major centres of maritime trade from the Bronze Age onwards. This economic prosperity generated increased pressures on the local environment, through urbanization and harbour development.
Carayon, N., Kaniewski, D., Marriner, N., Morhange, C.   +3 more
core   +4 more sources

A Second Mortuary Hiatus on Lake Baikal in Siberia and the Arrival of Small-Scale Pastoralism [PDF]

, 2017
Peer reviewedPublisher ...
Kharinskii, Artur A., Losey, Robert J., Nomokonova, Tatiana, Waters-Rist, Andrea L.   +3 more
core   +1 more source