Results 101 to 110 of about 70,887 (266)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

THROMBOLYTIC TREATMENT AND DRAMATIC IMPROVEMENT OF THE CLINICAL PICTURE IN A PATIENT WITH ACUTE OCCLUSION OF THE MIDDLE CEREBRAL ARTERY FOLLOWED BY TRANSCRANIAL DOPPLER SONOGRAPHY

Zdravniški Vestnik, 2004
Background. Thrombolytic treatment of ischemic cerebral stroke by means of a recombinant tissue plasminogen activator can be very successful in selected patients.
Erih Tetičkovič, Marija Menih
doaj  

A Voxel‐Wise T2 Distribution Framework for Lesion Severity Stratification and Treatment‐Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid‐Induced Neuroprotection

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90‐min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel‐wise T2 distribution framework.
Andrea Díaz‐Pérez, Clara Penas, Francesc Jiménez‐Altayó, Silvia Lope‐Piedrafita   +3 more
wiley   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

A catastrophic confluence: Concurrent subarachnoid haemorrhage and acute mesenteric ischaemia

Surgical Practice, EarlyView.
Abstract Background Acute mesenteric ischaemia (AMI) and subarachnoid haemorrhage (SAH) are life‐threatening emergencies with diametrically opposed treatment requirements regarding anticoagulation. This report describes a rare, complex case where both conditions occurred simultaneously, creating a significant therapeutic dilemma. Case presentation A 64‐
Ip Ki Fung Shavonne
wiley   +1 more source

Contrast‐Induced Encephalopathy Following Elective Endovascular Aneurysm Treatment: The Role of Dual‐Energy CT and Correlation With Delphi Diagnostic Criteria

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Contrast‐induced encephalopathy (CIE) is an increasingly recognised neurological complication of iodinated contrast administration during neurointerventional procedures. Recently published 2025 Delphi‐based diagnostic criteria and management algorithms aim to standardise clinical practice; however, optimal neuroimaging strategies ...
Kaiwen Cabbabe, Charles Li, Shuangyue Tan, Lisa Broadley, Gerard S. Goh, Cameron Williams, Conor Houlihan, Helen Kavnoudias, Steve Bush, Carlos Chung, Winston Chong   +10 more
wiley   +1 more source

Diagnóstico clínico diferencial entre oclusão da artéria carótida interna e da artéria cerebral média A comparative symptomatological study of internal carotid artery occlusion and middle cerebral artery occlusion

Arquivos de Neuro-Psiquiatria, 1971
Foi feito um estudo comparativo entre o quadro clínico inicial de 61 casos de oclusão da artéria carótida interna e o de 23 casos de oclusão da artéria cerebral média, diagnosticados pela angiografia cerebral e/ou pela necropsia em pacientes submetidos ...
Roberto Melaragno, Wilson Luíz Sanvito, Mario Cinelli Junior, Anoi Castro Cordeiro   +3 more
doaj