Results 201 to 210 of about 589,671 (265)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

On the Identification of the Middle Class [PDF]

open access: possible, 2013
The paper examines the identification of the “middle class” using data from LIS and LWS. It first considers definitions based purely on income, examining the rationale for different approaches and illustrating the implications for changes over time. It argues that the concept of “class” requires the examination of other dimensions beyond income.
Anthony B. Atkinson, Andrea Brandolini
openaire   +1 more source

The Manifesto and the Middle Class

Critical Sociology, 2001
This paper examines Marx's claim in the Manifesto that capitalist society would polarize into two classes in light of the current evidence on growing inequality in American society. It argues that the middle class of industrial society is not an anomaly but a product of the incomplete development of capitalism and this middle class is presently being ...
openaire   +1 more source

On the Middle Class [PDF]

open access: possible, 2013
The Middle class as a concept has evolved over time, taking on various meanings at various points throughout history, becoming an object to aspire to for poor people, an object of desire for a strong government, a buzzword for politicians the world over, and the source of new customers for firms, and the global economy more broadly.
Michael MacLennan   +1 more
openaire   +2 more sources

Middle Classes

2017
This issue of the Caucasus Analytical Digest discusses Middle Classes in the South Caucasus; Yuliana Melkumyan gives a systematic overview of the main features of the middle class in Armenia based on their self-perception as captured in representative surveys; Alexi Gugushvili posits that ‘the middle class’ in the Georgian context is still largely in ...
Melkumyan, Yuliana   +2 more
openaire   +2 more sources

The New Middle Class: I

1951
Abstract IN the early nineteenth century, although there are no exact figures, probably four-fifths of the occupied population were self-employed enterprisers; by 1870, only about one-third, and in 1940, only about one-fifth, were still in this old middle class.
openaire   +1 more source

The Middle Class

2022
This chapter analyzes the status of the middle class in America. It starts with defining the middle class; it continues with the danger of shrinking and tries to provide a mind genomics approach to middle-class problems. Analyzing the middle class in-depth is essential as it holds the key to the country's future.
openaire   +1 more source

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