Total Neoadjuvant Therapy for Rectal Cancer: Why Japan Says “Not Yet”
ABSTRACT Total neoadjuvant therapy (TNT) has rapidly gained global acceptance as a standard treatment for locally advanced rectal cancer (LARC). Supported by multiple phase III trials, TNT improves pathological complete response (pCR) rates, enhances systemic control, and expands opportunities for non‐operative management (NOM).
Kay Uehara +4 more
wiley +1 more source
Interventions, adaptive strategies and best practices improving maternal nutritional health in changing climatic conditions and diverse cultural contexts in low- and middle-income countries: a systematic review protocol. [PDF]
Bhanbhro S +8 more
europepmc +1 more source
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen +6 more
wiley +1 more source
Developmental changes in phonological awareness in Chinese-English bilingual children: An fNIRS longitudinal study. [PDF]
Li YL +5 more
europepmc +1 more source
Databases, Dictionaries and Dialectology. Dental instability in Early Middle English: A case study [PDF]
Laing, Margaret, Lass, Roger
core
ABSTRACT Background To mitigate the progression of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD), appropriate drain management is required, and exchanging drainage tubes is commonly performed. However, the optimal timing of the first drain exchange has not yet been determined.
Taihei Soma +7 more
wiley +1 more source
Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50 years and older: findings from two prospective cohort studies. [PDF]
Dong X +7 more
europepmc +1 more source
This study evaluated the impact of distal resection margin (DRM) length on recurrence in 208 patients undergoing surgery for rectal neuroendocrine tumors (NETs). Our findings demonstrate that while oncological safety must unquestionably remain the top priority, a short pathological DRM (< 10 mm) does not increase recurrence risk when R0 resection is ...
Kentaro Sato +8 more
wiley +1 more source
Facilitators and barriers primary care physicians face in providing palliative care in low- and middle-income countries: a mixed methods systematic review. [PDF]
Fernando G +4 more
europepmc +1 more source

