Results 111 to 120 of about 10,310,429 (285)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Türk lise İngilizce öğretmenleri tarafından en çok kullanılan web 2.0 araçları üzerine bir çalışma.

, 2019
This survey study reports the results of a survey which was conducted with high school Turkish EFL teachers in Turkey to find out the most commonly used Web 2.0 tools in English language teaching in high schools in Turkey and the advantages and ...
Kayar, Sümeyra
core  

Some Observations on the First Middle English Translation of the Revelation of John

Filologia Germanica
The Revelation of John represents one of the most popular texts of medieval Europe. This popularity, undoubtedly fuelled by fears and expectations of the year one thousand, is reflected not only in the presence of millenarian themes in contemporary ...
Letizia Vezzosi
doaj   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source

İngilizceyi yabancı dil olarak öğrenenlerin İngilizce telaffuz tercihini etkileyen sosyo-psikolojik etkenlerin araştırılması: sınıf içinde İngilizce telaffuzu belirleyen normlar ve olumsuz değerlendirilme korkusu arasındaki ilişki

, 2008
This thesis aims to investigate socio-psychological factors that affect foreign language learners’ pronunciation and focuses on the relationship between in-class injunctive norms for English pronunciation and Fear of Negative Evaluation (FNE). Injunctive
Ölçü, Zeynep
core  

An Efficient Biological Codon Recognition Reservoir Computing System Based on Low‐Energy Epitaxial Hf0.52Zr0.48O2 Ferroelectric Memristors

Advanced Science, EarlyView.
This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu, Jikang Xu, Yongqing Jia, Wenxuan Wang, Weifeng Zhang, Biao Yang, Xiaobing Yan   +6 more
wiley   +1 more source

CAI Portfolio English 111 : a new direction for freshman composition at Middle Tennessee State University.

, 1998
Advisers: Ayne Cantrell; William Connelly.A paradigm shift occurred in writing instruction theory and pedagogy during the 1970's, a shift that mandated a move away from the current-traditional emphasis on product and towards a new, more rhetorically ...
Clayton, Maria
core  

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Avrupa Birliği İngilizce dil portföyü ve Avrupa ortak başvuru metni'nde tanımlanan öğretmenler için gerekli özelliklerin öğretmenler tarafından şu an sahip oldukları ve ulaşmak istedikleri özellikler çerçevesinde nasıl algılandığını ortaya çıkarmak: örnek olay incelemesi

, 2008
The purpose of this study is to find out the required teacher competencies in the implementation of the Common European Framework (CEF) and the English Language Portfolio (ELP) and to explore the perceptions of teachers about their current and desired ...
Tandıroğlu, Işıl
core  

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source