Results 31 to 40 of about 1,418 (264)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Revue Archéologique de l’Est, 2007 The rescue excavation carried out before construction of an underground car park in the place Benoît Crépu on the right bank of the Saône river in Lyon has given archaeologists an extensive insight into the evolution of this area marked by its naturally ...
Grégoire Ayala
doaj +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
Internet Archaeology, 2021 Excavations along an 18.5km stretch of the Angelinos trunk water main in north Oxfordshire between Tackley and Milton uncovered a panoply of prehistoric to post-medieval remains.
Owain Scholma-Mason +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Pskov-style earthenware in Estonia from the 11th to the 15th centuries: types, subtypes and their distribution areas [PDF]
Eesti ArheoloogiaajakiriPskovÂ-style earthenware was widely used in Estonia from the 11th to the 18th centuries, and it can be divided into six typoÂ-chronological types.
Andres Tvauri
doaj +1 more source
Middle Iron Age Settlement and Ceramics at Highfields Caldecote, Cambridgeshire
, 2022 Excavations at Highfields, Caldecote, revealed an area of (initially unenclosed) Middle Iron Age settlement characterised by the remains of roundhouses and enclosure/boundary ditches, associated with which was a substantial pottery assemblage.
Brudenell, Matthew, Blackbourn, Kathryn
openaire +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Occupations domestique et funéraire de l’Âge du Fer à Lavau (Aube)
Revue Archéologique de l’Est, 2007 This paper deals with the results of an archaeological excavation (Inrap) carried out in the district of Lavau (Aube). Two sites have been clearly recognized : a part of a rural settlement from the Late Bronze Age/early Iron Age and a small cemetery from
Raphaël Durost +2 more
doaj +1 more source