Results 71 to 80 of about 68,539 (267)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Risk Factors for Small‐for‐Size Syndrome Grade B/C After Simultaneous Splenectomy in Adult Living‐Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
In a single‐center cohort of 577 adult LDLT recipients who underwent simultaneous splenectomy, clinically significant SFSS grade B/C (ILTS‐iLDLT‐LTSI 2023) occurred in 18.2% and was associated with inferior graft survival. Multivariate analysis identified MELD ≥ 30, NLR ≥ 4.5, and donor age ≥ 50 years as independent risk factors, which risk rising ...
Kyohei Yugawa, Takeo Toshima, Shinji Itoh, Takashi Motomura, Shohei Yoshiya, Norifumi Iseda, Tomoharu Yoshizumi   +6 more
wiley   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Pulmonary embolism as the presenting symptom and a confounder in ACTH-secreting bronchial carcinoid

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Ectopic ACTH-secreting pulmonary neuroendocrine tumors are rare and account for less than 5% of endogenous Cushing’s syndrome cases. We describe an unusual case of metastatic bronchial carcinoid tumor in a young woman presenting with unprovoked pulmonary
Wei Yang, David Pham, Aren T Vierra, Sarah Azam, Dorina Gui, John C Yoon   +5 more
doaj   +1 more source

Middle lobe syndrome: a retrospective analysis

, 2013
Background: This study aims to evaluate the efficacy middle lobe syndrome (MLS) surgery in patients with recurrent pulmonary infections. Methods: We retrospectively reviewed 37 cases (19 females, 18 males; mean age 12.3 years; range 6 to 55 years) who ...
Sahin, Atalay, Eren, Tahir Sevval, Meteroglu, Fatih   +2 more
core   +1 more source

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Macleod syndrome accompanied by right middle lobe agenesis

, 2010
Yaklaşık 1 yıldır eforla olan ve son bir aydır artan nefes darlığı, halsizlik, kilo kaybı ve çarpıntı şikayetleriyle başvuran 70 yaşındaki bayan hastada yapılan radyolojik tetkikler sonucu sağ akciğer orta lob agenezisi ve sağ alt lobda lokalize Macleod ...
Nuray Kömüş, Murat Yalçın, Özer Özyurt, Fidan Yıldız, Dilek Öncel, Mustafa Sever   +5 more
core  

Defining Features of Gabriele‐de Vries Syndrome in Adults: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gabriele‐de Vries syndrome (GADEVS) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in the YY1 gene. Like most rare genetic syndromes, the adult manifestations of GADEVS remain poorly defined. Here, we describe the oldest patient reported to date with GADEVS—a 63‐year‐old woman with a c.1177_1179del YY1 variant ...
Ethan W. Hollingsworth, Changrui Xiao
wiley   +1 more source

Radiological patterns in sickle cell disease patients with acute chest syndrome: Are there age-related differences?

Saudi Journal of Medicine and Medical Sciences, 2019
Background: Acute chest syndrome is a major cause of pulmonary disease and mortality in sickle cell disease patients. Its diagnosis can be delayed due to differing imaging patterns between children and adults.
Abdulaziz Mohammad Al-Sharydah, Mohammed Alshahrani, Bander Aldhaferi, Afnan Fahad Al-Muhanna, Hanadi Al-Thani   +4 more
doaj   +1 more source

Endoscopic aspects of Middle Lobe Syndrome [PDF]

INTRODUCTION Middle lobe syndrome is a term used in pulmonology to denote a number of pathological conditions accompanied by atelectasis and a decrease in the volume of the middle lobe.
Bushev, Jane, Trajkovska, Vanche, Baloski, Marjan, Poposki, Bozidar, Buklioska Ilievska, Daniela, Kochovska-Kamchevska, Nade, Jovevska, Svetlana   +6 more
core