This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Green Hydrogen Produced by Solar Thermal Separation Has Technical, Economic, and Environmental Aspirations [PDF]
In this paper, the generation of green hydrogen utilizing the sun powered warm partition strategy is analyzed from a financial and natural point of view, and the arrangements of researchers and analysts to create this innovation and decrease its costs ...
Salah Al-Haidari Zaid +3 more
doaj +1 more source
Italy seen through British eyes: a European middle power? [PDF]
This article analyses the British perceptions of contemporary Italy and Italian politics. Through the use of a number of sources (parliamentary debates, governmental documents, newspaper articles and interviews) it argues that Italy is not perceived ...
Andretta +5 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Call for Self-Study in Middle Level Teacher Education [PDF]
To promote dialogue and in response to calls for rigorous, large-scale, empirical studies as the standard that will move the field of middle level education forward, a collaborative of middle level teacher researchers submit three counterpoints to the ...
Falbe, Kristina N +2 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The Power of Music in the Tale of Beren and Lúthien by J.R.R. Tolkien [PDF]
Tolkien valued music in his private life, and this is mirrored in his works about Middle-Earth, which owes its very existence to music. It is born out of the song of the Ainur.
Klag, Katarzyna Wiktoria
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Performance Augmentation of Household Batch Digester using a Circular Horizontal Extended Surface
The digester geometry significantly enhances household batch digesters' performance, especially the internal surface area. The present study investigates the impact of different extended surface areas augmented around inside digesters on anaerobic ...
Ammar H. Soheel +2 more
doaj +1 more source

