Results 81 to 90 of about 3,690,024 (303)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

South Korea amid US-China strategic competition: strategy and limitations of a middle power

Revista CIDOB d'Afers Internacionals
This is an analysis of the evolution of South Korea’s foreign policy amid intensifying US-China strategic competition. From a neoclassical realist framework, it examines the strategies of the Lee, Park, Moon and Yoon administrations (2008-2025 ...
Just Castillo Iglesias, Paula Martínez Gual   +1 more
doaj   +1 more source

“MIDDLE POWERS” AS AN ELEMENT OF THE MODERN WORLD SYSTEM: ON THE THEORETICAL UNDERSTANDING OF THE CONCEPT

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018
The main theoretical approaches to the analysis of the concept of “middle power” are examined: hierarchical, regulatory, and behavioral. Each of these approaches uses a different set of criteria for inclusion of a state in the category of “middle powers”.
N. Y. Zhukovskaya
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Regional Politics in a Highly Fragmented Region: Israel’s Middle East Policies [PDF]

The region of the Middle East is highly conflict-loaded. The absence of one distinct regional power may be considered both cause and consequence of this structural feature.
Martin Beck
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A New Stage of the Italian Policy in Central Asia [PDF]

Современная Европа
The article examines the policy of the Italian Republic in Central Asia, which received additional impetus with the beginning of the Russian-Ukrainian conflict.
E.S. Alekseenkova
doaj   +1 more source

Haluan Baru Politik Luar Negeri Indonesia: Perbandingan Diplomasi ‘Middle Power\u27 Susilo Bambang Yudhoyono dan Joko Widodo [PDF]

, 2017
This article attempts to identify changes in Indonesia\u27s middle power diplomacy strategy under President Susilo Bambang Yudhoyono and Joko Widodo. This phenomenon is important to be studied because President Yudhoyono and President Widodo proposed ...
Alvian, R. A. (Rizky), Ardhani, I. (Irfan), Putri, G. C. (Ganesh)   +2 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source