Results 101 to 110 of about 905,343 (311)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Iran and Saudi Arabia in the Middle East: leadership and sectarianism (2011-2017)
Vestnik RUDN. International Relations, 2018 Relations between Iran and Saudi Arabia have never been at a desirable level. Iran’s 1979 revolution, the fall of Saddam Hussein in Iraq and the Arab Spring in turn increased the disagreement between the two regional powers.
Behzad Diansaei
doaj +1 more source
Book review: middle kingdom and empire of the rising sun: Sino-Japanese relations, past and present by June Treufel Dreyer [PDF]
, 2016 In Middle Kingdom and Empire of the Rising Sun: Sino-Japanese Relations, Past and Present, June Treufel Dreyer reflects on the current fraught relationship between Japan and China by placing their long-standing rivalry in deep historical context.
Treufel Dreyer, June
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Civilian knowledge industries and the ascendance of small and medium-sized states in world politics
Humanities & Social Sciences CommunicationsIn the evolving landscape of international politics, the ascent of small and medium-sized (SMS) states in knowledge industries is notable. As these states, exemplified by Israel, Sweden, Singapore, and the United Arab Emirates, harness advanced ...
Nir Hassid, Eviatar Matania
doaj +1 more source
Regional Politics in a Highly Fragmented Region: Israel’s Middle East Policies [PDF]
The region of the Middle East is highly conflict-loaded. The absence of one distinct regional power may be considered both cause and consequence of this structural feature.
Martin Beck
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The Role of the Judiciary in the Protection of Human Rights and Development: A Middle Eastern Perspective [PDF]
, 2002 One of the vital ways to keep human rights safe is by preserving the prevailing role of the judiciary. Standards developed by the judiciary have a significant beneficial effect of making the lives of people better and the accomplishment of the government\
Abul-Ethem, Fahed
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source