Results 91 to 100 of about 1,817,169 (313)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optics curriculum for middle school students [PDF]

SPIE Proceedings, 1995
A two-week course in optics has been developed and taught as part of the APEX program at the University of Arizona. APEX, (Academic Preparation of EXcellence), is an early-outreach program for minority students in the middle schools of the greater Tucson area.
openaire   +1 more source

Strategies for Motivating Middle School Students [PDF]

, 2018
The study analyzed the strategies that were effective for motivating and engaging adolescent aged students. The study was conducted in a middle school located in a suburban school district in upstate New York.
Suhr, Katrina
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigation on the Attitude of Middle School Students with Depression in the City Toward Professional Psychological Help-Seeking

Patient Preference and Adherence
Na Yong,1 Yu-Ling Ren,2 Chun-Yuan Wang,3 Cong Yang4 1Mental Health Center, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China; 2Gao Ping Middle School, Nanchong, Sichuan, 637000, People’s ...
Yong N, Ren YL, Wang CY, Yang C
doaj  

Electrical Conductivity Protocol [PDF]

, 2003
The purpose of this resource is to measure the conductivity of water at a freshwater hydrology site. Students calibrate and take electrical conductivity measurements using an electrical conductivity meter.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mysteries of the Underground River [PDF]

, 2013
Have you ever heard of a river that that flows backwards? Mammoth Cave, the longest cave system in the world, has an underground river exhibiting reverse fl ow patterns since at least the 1960’s and most likely earlier.
Ryan, Susan, TK Stone Middle School Students, Toomey, Rick, Trimboli, Shannon R., Weber, Kim   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source