Results 141 to 150 of about 1,828,231 (314)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Internet addiction and social support in the association between learning burnout and emotional behavioral problems among returned migrant middle school students: a serial multiple mediations analysis

BMC Public Health
Objective The objectives of this study were to explore emotional behavioral problems (EBP) associated with learning burnout (LB) among returned migrant middle school students.
Fengjiao Ran, Rong Wu, Yuan Luo, Pengyu Ren, Yu Liu, Xi Luo, Xiantao Yang, Manting Gu, Zheng Yan, Anxie Tuo   +9 more
doaj   +1 more source

Association between external eating and dietary patterns among middle school students in Chongqing, China

Frontiers in Nutrition
BackgroundThe dietary pattern, serving as a comprehensive indicator of the nutritional intake of middle school students, plays a crucial role in guiding their health.
Yingjiao Deng, Yingjiao Deng, Yingjiao Deng, Yingjiao Deng, Lingxi Zhao, Linlu Guo, Linlu Guo, Linlu Guo, Linlu Guo, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yuanyuan Lan, Yuanyuan Lan, Yuanyuan Lan, Yuanyuan Lan, Youtao Mou, Youtao Mou, Youtao Mou, Youtao Mou, Wenhua Ran, Ling Liu, Zumin Shi, Yong Zhao, Yong Zhao, Yong Zhao, Yong Zhao, Yong Zhao   +28 more
doaj   +1 more source

Exploring Culturally Responsive Teaching and Student-Created Videos in an At-Risk Middle School Classroom [PDF]

, 2018
As the United States public school classrooms encounter notable shifts in student demographics and increased access to technology, teachers face the dual challenges of cultural and digital differences as they attempt to build relationships with students ...
Mackay, Hannah, Strickland, Martha J.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Increasing Suicide Mortality of Female Students Became Greater than Males in Current Japan

Adolescents
In Japan, national crude suicide mortality rates (CMR-suicides) consistently decreased during the 2010s, whereas adolescent CMR-suicides have increased from the mid-2010s.
Ryusuke Matsumoto, Tomoka Oka, Eishi Motomura, Motohiro Okada   +3 more
doaj   +1 more source

Flourish or Fail?: The Risky Reward of Elite High School Admission in Mexico City [PDF]

, 2017
Admission to an elite school imposes substantial risks on many students while offering modest academic benefits relative to admission in their most preferred nonelite school.
Dustan, Andrew, Janvry, Alain de, Sadoulet, Elisabeth   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Salinity Titration Protocol [PDF]

, 2003
The purpose of this resource is to measure the salinity of the water using a salinity titration kit. Students will measure the salinity of saltwater using a salinity titration kit.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source