Results 61 to 70 of about 180,442 (265)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The effect of special exercises according to the principle of re-training in the development of kinesthetic perception among middle school students

الرياضة المعاصرة, 2020
The importance of research that has manifested in raising the level of perception and its different types for students in the intermediate stages of education using a method and principle from the principles of mathematical training science is repeated ...
Dr. Shaimaa Ali
doaj   +1 more source

Middle school students' and mathematicians' judgments of mathematical typicality

Journal of Numerical Cognition, 2018
K-12 students often rely on testing examples to explore and determine the truth of mathematical conjectures. However, little is known about how K-12 students choose examples and what elements are important when considering example choice. In other domains, experts give explicit consideration to the typicality of examples – how representative a given ...
Walkington, Candace, Cooper, Jennifer, Leonard, Olubukola, Williams-Pierce, Caroline, Kalish, Chuck   +4 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Effects of Parental Marital Status on Negative Emotions and Nonsuicidal Self-injury Behaviors in Middle School Students: a Multicenter Cross-sectional Study [PDF]

Zhongguo quanke yixue
Background Effects of parental marital status on nonsuicidal self-injury (NSSI) behaviors and negative emotions in adolescents have been rarely reported, and the existing research sample size is relatively small.
REN Xiaohong, CEN Yu, LUO Jing, ZHOU Yuling, HE Jinlong, LIN Cen, WU Dapeng, LUO Jiaming
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The relationship between parental phubbing and bullying behavior in middle school students: the mediating role of family closeness and negative emotions

BMC Psychology
Purpose This study examined the mediating role of family closeness and negative emotions in the relationship between parental phubbing and bullying behavior in middle school students.
Ganggang Pang, Caixia Wang, Cheng Kang
doaj   +1 more source

The Effect of Task- Performance Model Practice in Social Casework on Reducing Electronic Addiction Risks among Middle- School Students [PDF]

مجلة مستقبل العلوم الإجتماعیة
The current research investigated the effect of a professional intervention program using the Task-Performance model on reducing electronic addiction risks among middle- school students.
احمد وجيه الدسوقى المرسى
doaj   +1 more source