Results 151 to 160 of about 736,642 (345)

Approaches to Middle Stone Age landscape archaeology in tropical Africa

, 2016
David Wright, Jessica C. Thompson, Flora Schilt, Andrew S. Cohen, Jeong‐Heon Choi, Julio Mercader, Sheila Nightingale, Christopher E. Miller, Susan M. Mentzer, Dale Walde, Menno Welling, Elizabeth Gomani‐Chindebvu   +11 more
openalex   +2 more sources

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Climate frameworks for the Middle Stone Age and Later Stone Age in Northwest Africa

Quaternary International
This paper examines climate conditions in Northwest Africa for Marine Isotope Stage 4, 3, and 2 (71,000–11,000 years ago) and their impact on the distribution of potential suitable areas on a regional scale. The analysis uses climate simulations to model: 1) the geographical extent and variability of macro-refugia based on ethnographic data; and 2) the
Solène Boisard, Colin D. Wren, Lucy Timbrell, Ariane Burke   +3 more
openaire   +2 more sources

Sediment micromorphology and site formation processes during the Middle to Later Stone Ages at the Haua Fteah Cave, Cyrenaica, Libya [PDF]

, 2017
Robyn Inglis, Charles French, Lucy Farr, Chris Hunt, Sacha Jones, Tim Reynolds, Graeme Barker   +6 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Constraining the age of the Middle Stone Age locality of Bargny (Senegal) through a combined OSL-ESR dating approach

Quaternary Environments and Humans
The Middle Stone Age (MSA) is the major chrono-cultural phase associated with the emergence and evolution of Homo sapiens in Africa. Despite its importance, the MSA has not been evenly investigated across Africa, and West Africa in particular remains ...
E. Ben Arous, K. Niang, J.A. Blinkhorn, M. Del Val, A. Medialdea, C. Coussot, M.J. Alonso Escarza, M.D. Bateman, A. Churruca Clemente, A.F. Blackwood, J. Iglesias-Cibanal, C. Saíz, E.M.L. Scerri, M. Duval   +13 more
doaj   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Heat treatment in the South African Middle Stone Age: temperature induced transformations of silcrete and their technological implications

, 2012
Patrick Schmidt, Guillaume Porraz, Aneta Slodczyk, Ludovic Bellot‐Gurlet, William Archer, Christopher E. Miller   +5 more
openalex   +2 more sources

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

Advanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim, Hanjun Hwangbo, ByungJoon Choi, Dogeon Yoon, GeunHyung Kim   +4 more
wiley   +1 more source