Results 251 to 260 of about 1,400,953 (307)

Medial migration of a tympanostomy tube after 30 years: a rare case report. [PDF]

J Surg Case Rep
Hajr E.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Long-term outcomes of middle ear regenerative therapy using cell sheet transplantation combined with tympanoplasty. [PDF]

Regen Ther
Yamamoto K, Morino T, Baba A, Kasai Y, Takizawa Y, Fukuda N, Kikuchi S, Yamamoto Y, Yamato M, Kojima H.   +9 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A study of trends and projection of life expectancy and its association with socio-demographic index: Results from GBD study 2023. [PDF]

PLoS One
Taherian R, Karimi Ghahfarokhi M, Zayeri F.   +2 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Comparison of the predictive value of CONUT, NLR, and PNI for 6-month and 1-year mortality in middle-aged and older adults with hip fractures: a retrospective study. [PDF]

Front Nutr
Chen ZQ, Lin L, Huang CZ, Zheng YQ, Lin MM, Fang YZ, Wang ZF, Zhang CH, Zhang JS, Liu XF.   +9 more
europepmc   +1 more source

Utility of multivessel Doppler assessment for predicting adverse neonatal outcome in late-onset intrauterine growth restriction. [PDF]

Rev Assoc Med Bras (1992)
Karkin PÖ, Kalelioğlu İH.
europepmc   +1 more source

Reconceptualizing Childhood Enuresis: A Biopsychosocial Medical Family Therapy Approach. [PDF]

Int Neurourol J
Jeon H, Kim J.
europepmc   +1 more source