Results 71 to 80 of about 1,400,953 (307)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Mapping Global Middle Ages, Toward a Global Middle Ages
, 2019 In Order to understand what a "global Middle Ages" might be, we need to define "global" in and in relation to the "Middle Ages." To do so, I turn to medieval (Christian) maps.
Asa Simon Mittman, Bryan C. Keene
core +1 more source
A comparison between dinosaur footprints from the Middle Jurassic of the Isle of Skye, Scotland, UK, and Shell, Wyoming, USA [PDF]
, 2008 Measurements of Middle Jurassic tridactyl dinosaur tracks from the Bathonian, Lealt Shale, Valtos Sandstone, Duntulm and Kilmaluag formations of the Isle of Skye, UK, are compared to the same measurements taken for dinosaur footprints from the Bajocian ...
Brett-Surman, M.K., Clark, N.D.L.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Vulnerability Detection on Solidity Smart Contracts by Using Convolutional Neural Networks [PDF]
, 2023 Smart contracts, which are self executing contracts with the terms of the agreement between buyer and seller being directly written into lines of code, have the potential to revolutionize many industries by automating complex processes and reducing the ...
BEKTAŞ, Barış Cem
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Is there a missing-middle in Australian mental health care?
, 2021 OBJECTIVE: The term 'missing-middle' has been prominent in discourse relating to provision of mental health care in Australia, particularly by proponents of non-governmental youth mental health services such as headspace and related adult services.
Stephen R, Kisely +3 more
core +1 more source
Systems-disconjugacy of a fourth-order differential equation with a middle term
Electronic Journal of Differential Equations, 2016 Systems-conjugate points were introduced and studied by Barrett [3] in relation with the self-adjoint fourth order differential equation $$ (r(x)y'')''-(q(x)y')'= p(x)y, $$ where r(x)>0, p(x)>0 and q=0. In this paper we extend some of his results
Jamel Ben Amara
doaj