Results 181 to 190 of about 5,127 (205)
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Chest, 2013
Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin glue, or talc pleurodesis; few successful medical ...
Heather Warren +6 more
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Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin glue, or talc pleurodesis; few successful medical ...
Heather Warren +6 more
openaire +3 more sources
Midodrine for the weaning of vasopressor infusions
Journal of Clinical Pharmacy and Therapeutics, 2016Midodrine, an orally available α1-agonist indicated for the treatment of orthostatic hypotension, has been used at our institution as an adjunctive treatment to provide haemodynamic support to facilitate intravenous (IV) vasopressor weaning. Limited published data exist for this off-label use; thus, the objective of this study was to evaluate outcomes ...
L. B. Poveromo +2 more
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Pharmacodynamics of midodrine, an antihypotensive agent
Clinical Pharmacology and Therapeutics, 1986Midodrine is an orally active adrenergic agonist useful in the treatment of hypotension. We have investigated the pharmacodynamics of its active metabolite after oral midodrine therapy in nine patients with severe orthostatic hypotension. Peak plasma levels of the metabolite were reached in 60 to 90 minutes and ranged from 25 to 56 ng/ml.
Prince K. Zachariah +11 more
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Intestinal obstruction associated with oral midodrine
Clinical Autonomic Research, 2004We report a case of severe ileus possibly related to midodrine. To our knowledge, this case report is the first one suggesting an inhibitory effect of midodrine on intestinal motility. The potential pharmacological mechanisms leading to this adverse drug reaction are discussed below.
Michel Galinier +4 more
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Midodrine Hydrochloride in the Treatment of Vasovagal Syncope
Pacing and Clinical Electrophysiology, 1999Therapy of vasovagal syncope is still a subject of debate. Various pharmacotherapies were proposed. However, they are often not tolerated or ineffective. The purpose of this prospective, nonrandomized study was to evaluate the usefulness of alpha‐agonist midodrine hydrochloride in the treatment of vasovagal syncope.
Dusan Trejbal +2 more
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Effects of Promethazine and Midodrine on Orthostatic Tolerance
Aviation, Space, and Environmental Medicine, 2011Astronauts experience both orthostatic hypotension and space motion sickness during re-entry. Midodrine, an alpha1-adrenergic agonist, is used to treat orthostatic hypotension. Promethazine, a histamine H1-receptor antagonist, is prescribed for space motion sickness. Many astronauts need both midodrine and promethazine.
Michael G. Ziegler +3 more
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Midodrine treatment in children with recurrent vasovagal syncope
Cardiology in the Young, 2021AbstractBackground:Vasovagal syncope is the most common cause of syncope in childhood and its treatment is not at a satisfactory level yet. We aimed to investigate patients who were diagnosed with vasovagal syncope, did not benefit from conventional treatment, received midodrine treatment, and to evaluate their response to midodrine treatment.Methods ...
Denizhan Bagrul +4 more
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Midodrine for severe orthostatic hypotension
Drug and Therapeutics Bulletin, 2016Midodrine (Bramox—Brancaster Pharma Limited) was authorised in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA) in March 2015 for “the treatment of severe orthostatic hypotension due to autonomic dysfunction in adults when corrective factors have been ruled out and other forms of treatment are inadequate”.1Previously, midodrine ...
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Observations on midodrine in a case of vasodepressor neurogenic syncope
Clinical Autonomic Research, 1995A 43-year-old man presented with recurrent syncope and dizziness after he had a dual chamber pacemaker fitted for presumed sino-atrial disease. Head-up tilt produced vasodepressor neurocardiogenic syncope, despite appropriate heart rate support during pacing, and reproduced symptoms. Symptoms were not improved by disopyramide. A double-blind cross-over
Rose Anne Kenny, C. Ward
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Establishing the Efficacy of Midodrine to Prevent Vasovagal Syncope
Annals of Internal Medicine, 2021Sheldon and colleagues reported the efficacy of midodrine in a well-powered randomized trial. The editorialist discusses the findings and predicts that the future of therapy for recurrent vasovagal...
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