Results 231 to 240 of about 6,183 (280)

Midodrine for the weaning of vasopressor infusions

Journal of Clinical Pharmacy and Therapeutics, 2016
Midodrine, an orally available α1-agonist indicated for the treatment of orthostatic hypotension, has been used at our institution as an adjunctive treatment to provide haemodynamic support to facilitate intravenous (IV) vasopressor weaning. Limited published data exist for this off-label use; thus, the objective of this study was to evaluate outcomes ...
L. B. Poveromo, Elizabeth Landrum Michalets, S. E. Sutherland   +2 more
openaire   +3 more sources

Pharmacodynamics of midodrine, an antihypotensive agent

Clinical Pharmacology and Therapeutics, 1986
Midodrine is an orally active adrenergic agonist useful in the treatment of hypotension. We have investigated the pharmacodynamics of its active metabolite after oral midodrine therapy in nine patients with severe orthostatic hypotension. Peak plasma levels of the metabolite were reached in 60 to 90 minutes and ranged from 25 to 56 ng/ml.
Prince K. Zachariah, Prince K. Zachariah, Duane C Bloedow, Duane C Bloedow, Thomas P. Moyer, Thomas P. Moyer, Robert D. Fealey, Robert D. Fealey, Alexander Schirger, Alexander Schirger, Sheldon G. Sheps, Sheldon G. Sheps   +11 more
openaire   +3 more sources

Effect of midodrine on the prognosis of patients with septic shock: a systematic review and meta-analysis.

European Review for Medical and Pharmacological Sciences, 2023
OBJECTIVE This study aims to assess the efficacy and safety of midodrine on treating patients with septic shock. MATERIALS AND METHODS Literature search was conducted in PubMed, the Cochrane Library, and Embase.
Qian He, Xiaokang Xing, T-Q Wang, Zhuojuan Jiang, G. Zhang   +4 more
semanticscholar   +1 more source

Using of Oral Midodrine in Weaning of Intravenous Vasopressors in Patients with Septic Shock Admitted to ICU

The Quarterly journal of medicine, 2023
Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. Diagnosis of septic shock is based on presence of certain symtoms,
Mohsen Abd El-Ghany Basiouny, G. Samir, Ahmed Farouk Ibrahim, Mohammed Ali Mohammed Mahmoud   +3 more
semanticscholar   +1 more source

Midodrine as Adjunction Support for Weaning off Norepinephrine in Septic Shock

The Quarterly journal of medicine, 2023
Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. To evaluate whether oral administration of midodrine is an
Hussien Gamal Mohammed Hafez, S. Nashed, Fady Adib Abd El Malek Morkos, Wael Abd El_Moneim Mohamed Abd El Wahab   +3 more
semanticscholar   +1 more source

Outcomes with inpatient use of midodrine in patients with heart failure and kidney failure on maintenance dialysis.

Acta Cardiologica
BACKGROUND Midodrine, an FDA-approved medication for orthostatic hypotension, is also used off-label to manage hypotension in dialysis patients, including those with heart failure.
Neev Patel, Bruno Álvarez Concejo, K. Lo, Meenakshi Mishra, A. Kattubadi, Janani Rangaswami   +5 more
semanticscholar   +1 more source

Intestinal obstruction associated with oral midodrine

Clinical Autonomic Research, 2004
We report a case of severe ileus possibly related to midodrine. To our knowledge, this case report is the first one suggesting an inhibitory effect of midodrine on intestinal motility. The potential pharmacological mechanisms leading to this adverse drug reaction are discussed below.
Michel Galinier, Atul Pathak, Jean-Louis Montastruc, Jean-Michel Senard, Pascaline Debats   +4 more
openaire   +3 more sources

Midodrine Hydrochloride in the Treatment of Vasovagal Syncope

Pacing and Clinical Electrophysiology, 1999
Therapy of vasovagal syncope is still a subject of debate. Various pharmacotherapies were proposed. However, they are often not tolerated or ineffective. The purpose of this prospective, nonrandomized study was to evaluate the usefulness of alpha‐agonist midodrine hydrochloride in the treatment of vasovagal syncope.
Dusan Trejbal, Peter Mitro, Rafael Rybár   +2 more
openaire   +3 more sources

The Impact of Midodrine Tapering Versus Nontapering Regimens on the Clinical Outcomes of Critically Ill Patients: A Retrospective Cohort Study

The Annals of Pharmacotherapy, 2023
Background: Midodrine has been used in the intensive care unit (ICU) setting to reduce the time to vasopressor discontinuation. The limited data supporting midodrine use have led to variability in the pattern of initiation and discontinuation of ...
PharmD Jawaher Gramish, PharmD Ahmed Hattan, PharmD Ohoud Aljuhani, PhD P. J. Parameaswari, PharmD Shaden Alshehri, PharmD Ghazwa B. Korayem, PhD Hadeel Alkofide, PharmD Mai Alalawi, PhD Ramesh Vishwakarma, PharmD Yazed Saleh Alsowaida, PharmD Rahaf Alqahtani, PharmD Luluh Binorayir, PhD Mohammed Abutaleb, PharmD Alanoud Alotaibi, MSc Majidah Aljohani, PharmD Sarah Aljohani, MSc Sana Samreen, PharmD Suad Jawhari, PharmD Raghad Alanazi, B. S. B. B. M. F. Khalid A. Al Sulaiman   +19 more
semanticscholar   +1 more source

Midodrine reduces new-onset acute kidney injury and hyponatremia in children with cirrhosis and ascites awaiting liver transplantation: Results from an open-label RCT.

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2023
OBJECTIVES Midodrine, an oral α-1-adrenergic receptor agonist, counters arterial hypovolemia and reduces complications in adult patients with cirrhosis.
A. Ashritha, B. B. Lal, R. Khanna, V. Sood, Arun K. Sood, S. Alam   +5 more
semanticscholar   +1 more source