Results 11 to 20 of about 5,819 (177)

Shared Decision-Making in Treatment Selection in Multiple Myeloma in Spain: The PRISMMA Study. [PDF]

Eur J Haematol
ABSTRACT Introduction Perceptions and experiences of shared decision‐making between patients and physicians in multiple myeloma (MM) care are not fully understood. A survey study was conducted to explore these perspectives in Spain. Methods Two anonymous online surveys, one for haematologists and one for MM patients, were developed.
Cabañas V, Casanova M, Barragán B, López I, Raya A, Santiago-Josefat B.   +5 more
europepmc   +2 more sources

JAK2 is a critical therapeutic target in VEXAS syndrome treated with ruxolitinib. [PDF]

Br J Haematol
British Journal of Haematology, Volume 206, Issue 2, Page 758-762, February 2025.
Ceccardi A, Dameri M, Ravera F, Gilardi N, Stabile M, Lombardo I, Ceresa D, Colombo M, Vigo T, Cigolini B, Rivoli G, Dragani M, Solimano I, Garuti A, Bellodi A, Ballestrero A, Ferrando L, Zoppoli G.   +17 more
europepmc   +2 more sources

M-protein-related necrobiotic granuloma in a multiple myeloma patient treated with daratumumab, lenalidomide and dexamethasone. [PDF]

Br J Haematol
British Journal of Haematology, Volume 206, Issue 1, Page 16-17, January 2025.
Bertuglia G, Bringhen S, Bruno B, Impalà GA, D'Agostino M.   +4 more
europepmc   +2 more sources

P853: AUTOMATED SEPARATION OF CELL CLUSTERS PROVIDES AN EASY AND ACCURATE STRATEGY FOR THE ANALYSIS OF MINIMAL RESIDUAL DISEASE IN MULTIPLE MIELOMA IN SINGLE 11-COLORS FLOW CYTOMETRY COMBINATION. [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
Piñero P, Gutierrez N, Gonzalez R, Diaz V, Marin E, Morillas M, Fernandes Junior E, López Marín J, Hernandez L, Manresa Manresa P, Hernandez M, Tarin F.   +11 more
europepmc   +2 more sources

Focal adhesion kinase activation by calcium‐dependent calpain is involved in chronic lymphocytic leukaemia cell aggressiveness

British Journal of Haematology, Volume 203, Issue 2, Page 224-236, October 2023., 2023
In chronic lymphocytic leukemia (CLL), the activation of B‐cell receptor and other signalling pathways promote the activation of focal adhesion kinase (FAK) and its subsequent calpain‐mediated cleavage following calcium (Ca2+) mobilization. FAK activation, together with HS1 and cortactin, two essential cytoskeletal proteins, lead to an aggressive ...
Filippo Severin, Nayla Mouawad, Edoardo Ruggeri, Andrea Visentin, Leonardo Martinello, Elisa Pagnin, Valentina Trimarco, Stefano Pravato, Francesco Angotzi, Monica Facco, Livio Trentin, Federica Frezzato   +11 more
wiley   +1 more source

Measurable Residual Disease Testing in Multiple Myeloma Routine Clinical Practice: A Modified Delphi Study

HemaSphere, Volume 7, Issue 9, September 2023., 2023
We used a modified Delphi approach to establish areas of consensus and nonconsensus regarding the utility of determining measurable residual disease (MRD) to assess multiple myeloma (MM) treatment response, which may inform disease management and design of future clinical trials.
Karthik Ramasamy, Hervé Avet‐Loiseau, Cecilie Hveding Blimark, Michel Delforge, Francesca Gay, Salomon Manier, Joaquín Martinez‐Lopez, Maria Victoria Mateos, Mohamad Mohty, Niels W.C.J. van de Donk, Katja Weisel   +10 more
wiley   +1 more source

Outcomes and prognostic factors in 3306 patients with relapsed/refractory chronic lymphocytic leukemia treated with ibrutinib outside of clinical trials: A nationwide study. [PDF]

Hemasphere
Abstract We performed a cohort study that included all patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) who received ibrutinib in the Italian National Health Service. With a median follow‐up of 42.2 months (IQR 30.8–54.6 months), the study involved 3306 patients with a median age of 72.1 years, of whom 42.6% had received ≥2 ...
Rigolin GM, Olimpieri PP, Summa V, Celant S, Scarfò L, Ballardini MP, Urso A, Gambara S, Cavazzini F, Ghia P, Cuneo A, Russo P.   +11 more
europepmc   +2 more sources

Additional lesions identified by genomic microarrays are associated with an inferior outcome in low‐risk chronic lymphocytic leukaemia patients

British Journal of Haematology, Volume 202, Issue 5, Page 953-959, September 2023., 2023
In newly diagnosed low‐risk CLL patients as defined by a standard 4 probe FISH analysis, additional lesions by GM were detected in 27 out of 119 patients (22.7%). The presence of additional lesions was associated with a shorter TTFT, independently of CLL‐IPI.
Gian Matteo Rigolin, Alice Traversa, Viviana Caputo, Ilaria Del Giudice, Antonella Bardi, Elena Saccenti, Sara Raponi, Caterina Ilari, Luciana Cafforio, Agnese Giovannetti, Antonio Pizzuti, Anna Guarini, Robin Foà, Antonio Cuneo   +13 more
wiley   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2-Dependent Mechanisms. [PDF]

Adv Sci (Weinh)
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Da Ros A, Benetton M, Borella G, Longo G, Borile G, Cani A, Lopez-Pigozzi D, Bortolozzi M, Bresolin S, Tregnago C, Locatelli F, Pigazzi M.   +11 more
europepmc   +2 more sources

Compliance with yellow fever and measles vaccines in the revaccination program post‐hematopoietic cell transplantation

Transplant Infectious Disease, Volume 25, Issue 4, August 2023., 2023
The vaccination records of 273 recipients after 2 years of hematopoietic cell transplant (HCT) were evaluated to verify if live‐attenuated viral vaccines (LAVV) were up to date. A total of 138 (50.5%) and 58 (21.2%) received measles and yellow fever vaccines, respectively. Most vaccinated patients were allo‐HCT.
Lucia H. de Almeida Testa, Anderson J. Simione, Ana Claudia F. dos Santos, Iago Colturato, Fernanda Barbieri, Mair Pedro de Souza, Vergilio R. Colturato, Clarisse M. Machado   +7 more
wiley   +1 more source