Results 1 to 10 of about 99 (99)

EEG Spectral Exponents and Visual Chirp Responses Mirror Anti‐Seizure Medication Load in Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Quantitative markers of cortical excitability may help identify responders to anti‐seizure medications (ASMs). We studied the relationship between ASM load and two electroencephalography (EEG) markers of cortical excitability in people with refractory epilepsy. Methods We included individuals with refractory focal epilepsy undergoing
Silvano R. Gefferie, Arthur R. van Nieuw Amerongen, Gerhard H. Visser, Maeike Zijlmans, Else A. Tolner, Mark van de Ruit, Arn M. J. M. van den Maagdenberg, Roland D. Thijs   +7 more
wiley   +1 more source

Patients' Global Impression of Change (PGIC) Score Compared to Monthly Migraine Days to Evaluate Treatment Persistence With Anti‐CGRP Monoclonal Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assessed whether continued treatment with anti‐CGRP monoclonal antibodies (mAbs) is driven more by reductions in monthly migraine days (MMDs) or patients' global impression of change (PGIC), a patient‐reported outcome. Among 169 patients treated with anti‐CGRP mAbs, 21.3% discontinued due to ineffectiveness. PGIC responders (≥ 5) at
Marina Romozzi, Catello Vollono, Paolo Calabresi, Francesco De Cesaris, Luigi Francesco Iannone   +4 more
wiley   +1 more source

Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐EEG and Associations With Sleep Parameters

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep spindles are an electrophysiological fingerprint of the sleeping human brain. They can be described in terms of duration, frequency, amplitude, and density, and vary widely according to age and sex. Spindles play a role in sleep and wake functions and are altered in several neurological and psychiatric disorders.
Julien Coelho, Heloïse Degros, Jean‐Arthur Micoulaud‐Franchi, Patricia Sagaspe, Emmanuel d'Incau, Paul Galvez, Christian Berthomier, Pierre Philip, Jacques Taillard   +8 more
wiley   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Ocular Findings as the Most Striking Manifestation of a SMAD3 Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Loeys‐Dietz syndrome (LDS) is a heritable connective tissue disorder with variable expressivity. It is a multisystemic condition mainly characterized by a propensity for arterial aneurysms and dissections, skeletal manifestations, hypertelorism, bifid uvula, craniosynostosis, and cutaneous features.
Noémie Villeneuve‐Cloutier, Christie A Boswell‐Patterson, Lucas Bronicki, Krista M. Vincent, Kalin Wilk, Andrea C. Yu, Gail E. Graham, Julie Richer   +7 more
wiley   +1 more source