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Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto +9 more
core +3 more sources
Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives
Chronic migraine is a disabling neurological disorder that imposes a considerable burden on individual and socioeconomic outcomes. Chronic migraine is defined as headaches occurring on at least 15 days per month with at least eight of these fulfilling ...
Tiffani J. Mungoven +2 more
doaj +2 more sources
Genetics of migraine: where are we now?
Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the ...
L. Grangeon +9 more
semanticscholar +1 more source
Background A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world
S. Sacco +17 more
semanticscholar +1 more source
Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities
Migraine affects more than one billion individuals each year across the world, and is one of the most common neurologic disorders, with a high prevalence and morbidity, especially among young adults and females.
P. Amiri +8 more
semanticscholar +1 more source
To incorporate recent research findings, expert consensus, and patient perspectives into updated guidance on the use of new acute and preventive treatments for migraine in adults.
J. Ailani, R. Burch, M. Robbins
semanticscholar +1 more source
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are ...
Heidi Hautakangas +72 more
semanticscholar +1 more source
Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces
BackgroundPrevious studies suggested a circadian variation of migraine attack onset, although, with contradictory results – possibly because of the existence of migraine subgroups with different circadian attack onset peaks. Migraine is primarily a brain
Daniel Baksa +31 more
doaj +1 more source

