Results 61 to 70 of about 124,603 (293)

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

The Journal of Headache and Pain, 2020
Background White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is limited research focused on the ...
Álvaro Planchuelo-Gómez, David García-Azorín, Ángel L. Guerrero, Santiago Aja-Fernández, Margarita Rodríguez, Rodrigo de Luis-García   +5 more
doaj   +1 more source

Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20–75 Years of Age

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Women with the FMR1 premutation (FXpm) are at heightened genetic vulnerability for depression, with risk compounded by the stressors of parenting a disabled child. Although risk factors persist as FXpm women age, depression in FXpm mothers during midlife and old age is poorly characterized. This study used an accelerated longitudinal design to
Jessica Klusek, Lauren Jenner, Abigail L. Hogan, Laura Friedman, Elizabeth Berry‐Kravis, Flora Tassone, Tatyana Adayev, Amanda J. Fairchild, Jane E. Roberts   +8 more
wiley   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

The problem of propranolol poisoning

British Journal of Clinical Pharmacology, EarlyView.
Aims Propranolol is licensed in the UK and elsewhere to relieve symptoms of anxiety. In overdose, propranolol poisoning can be serious, difficult to treat and potentially fatal. This paper describes cases of intentional propranolol overdose reported to the UK National Poisons Information Service in order to raise awareness of the risk of harm following
Hayley Williams, Pardeep Jagpal, Euan Sandilands, Emma Morrison, Laurence Gray, Harry Krishna Ruben Thanacoody, Elisha Beg, Sally Bradberry, Robin Ferner   +8 more
wiley   +1 more source

Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Combining nonprescription analgesics with different mechanisms of action has been proposed as a rational strategy to optimize the management of acute pain. This review assessed the efficacy and safety of nonprescription analgesics, including paracetamol (acetaminophen), metamizole and nonsteroidal anti‐inflammatory drugs (NSAIDs) used in combination vs.
Ali Mobasheri, Bart Morlion, Vidhu Sood Sethi, Mary Cardosa, Oscar Della Pasqua, Pranab Kalita   +5 more
wiley   +1 more source

Safety of Rimegepant in Adults with Migraine and Anxiety, Depression, or Using Antidepressants: Analysis of a Multicenter, Long-Term, Open-Label Study

Pain and Therapy
Introduction Anxiety and depression are frequently associated with migraine, and antidepressant use can complicate treatment. These analyses assessed the safety and tolerability of rimegepant in participants with migraine and anxiety and/or depression ...
David Kudrow, Susan Hutchinson, Glenn C. Pixton, Terence Fullerton   +3 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Diagnosis and Development of Screening Items for Migraine in Neurological Practice in Taiwan

Journal of the Formosan Medical Association, 2008
The objectives of this study were to: (1) survey migraine diagnoses among neurological outpatients in Taiwan; (2) compare neurologists’ migraine diagnoses with the International Classification of Headache Disorders 2nd Edition (ICHD-2) criteria; and (3 ...
Shuu-Jiun Wang, Jong-Ling Fuh, San-Yong Huang, Sheng-Shan Yang, Zin-An Wu, Chang-Hung Hsu, Chi-Hong Wang, Hsiang-Yu Yu, Po-Jen Wang   +8 more
doaj   +1 more source

Study on the Screening of Anti‐Osteoporosis Components in Processed Epimedium‐Based on Spectrum‐Effect Analysis

Chemistry &Biodiversity, EarlyView.
ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang, Jia Liu, Weixia Sun, Pan Li, Huaizhu Sun, Wenxuan Cao, Yulin Dai, Tianyang Xu, Peng Yu   +8 more
wiley   +1 more source