Results 81 to 90 of about 96,415 (362)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Migraine: Diagnosis, treatment and understanding c1960-2010 [PDF]

, 2014
seminar transcriptThere are around eight million migraine sufferers in the UK today. This Witness Seminar looked at the last 50 years of research into the diagnosis and treatment of the condition and the changing attitudes of the medical profession ...
Overy, C, Tansey, EM
core  

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification. [PDF]

, 2009
There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral ...
A Ferrari, A Fox, A Hershey, A Hershey, AI Scher, AI Scher, Alan M. Rapoport, B Bille, B. L. Peterlin, C Waeber, C Wober, D D’Amico, D Loder, D Marcus, DC Haas, Fred D. Sheftell, G Fuller, HF Boardman, I Abu-Arefeh, JA Charles, JA Charles, James A. Charles, JF Fries, JL Brandes, K Ahoen, KMA Welch, L Pageler, L Peterlin, M Fanicullace, MA Kabbouche, Marielle A. Kabbouche, MC Kruit, ME Bigal, NH Raskin, NT Mathew, NT Mathew, P Winner, R Burstein, R Burstein, R Hering-Hanit, R Lipton, R Monastero, R Petrella, S Solomon, SD Silberstein, SD Silberstein, SL Linder, SL Linder, SL Linder, Steven L. Linder, W Split, WF Stewart, WF Stewart   +52 more
core   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Risk of major mental disorders in the offspring of parents with migraine

Annals of General Psychiatry
Background Migraine has been associated with mental disorders, however whether parental migraine is associated with an increased risk of major mental disorders (MMDs) in offspring has not been investigated. We aimed to examine the risk of the development
Dian-Jeng Li, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen   +4 more
doaj   +1 more source

Comorbidity of migraine with ADHD in adults

BMC Neurology, 2018
Background Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population.
Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge, Kristoffer Burgdorf   +12 more
doaj   +1 more source

My migraine voice survey. aA global study of disease burden among individuals with migraine for whom preventive treatments have failed [PDF]

, 2018
Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering ...
Carboni, Veruska, Craven, Audrey, Diener, Hans-Christoph, Dumas, Paula, Evans, Simon, Fink, Rachel, Laflamme, Annik K., Lanteri-Minet, Michel, Martelletti, Paolo, Quintana, Rebeca, Rasmussen, Annette Vangaa, Ruiz De La Torre, Elena, Schwedt, Todd J., Vo, Pamela, Walsh, Donna   +14 more
core   +1 more source

Continuing medical education in epileptology: The Level 1‐2‐3 experience of the ILAE academy

Epileptic Disorders, EarlyView.
Abstract The International League Against Epilepsy (ILAE) Academy is the world's eminent e‐learning campus for epileptology. Its modular teaching content was developed to cover all competencies and learning objectives specified in the ILAE's curriculum for epileptology.
Ingmar Blümcke, Eva Biesel, Samuel Wiebe, Sandor Beniczky, Jo M. Wilmshurst, Man Mohan Mehndiratta, Ali A. Asadi‐Pooya, Christian Brandt, Alexis Arzimanoglou, Gagandeep Singh, on behalf of the ILAE Academy content development faculty, Raidah Al Baradie, Carmen Barba, Jocelyn F. Bautista, Sallie Baxendale, Elena Belousova, Isabella Brambilla, Jorge G. Burneo, Leonor Cabral‐Lim, Jaime Carrizosa, Jaume Campistol, Hannah Cock, Marion Comajuan, Helen Cross, Emilija Cvetkovska, Valentina De Giorgis, Luca De Palma, Kirsten A. Donald, Georg Dorfmüller, Guadalupe Fernandez Baca Vaca, Jessica Fesler, Irene García Morales, Christina Giavasi, Maria Gogou, Patricia Gómez Iglesias, Samson Gwer, Till Hartlieb, Martin Holtkamp, Floor E. Jansen, Bosanka Jocic‐Jakubi, Philippe Kahane, Ioannis Karakis, Takafumi Kubota, Joshua Laing, Tatjana Liakina, Aileen McGonigal, Rosa Michaelis, Ioana Mindruta, Andrew Neal, Maureen Njoroge, Irina Oane, Terence O’Brien, Finbar O’Callaghan, Manuela Ochoa Urrea, Nicholas Odero, Sebastián Ortiz, Karine Ostrowsky‐Coste, Maria T. Papadopoulou, Tiziana Pisano, Anna Rada, Stefan Rampp, Markus Reuber, Sylvain Rheims, Andrea O. Rossetti, Guido Rubboli, Victoria San Antonio‐Arce, Jan‐Christoph Schoene‐Bake, Artem Sharkov, Hugh D. Simpson, Mary Lou Smith, Ana Suller Marti, Rainer Surges, Roland Thijs, Joseph Toulouse, Bart van den Munckhof, Bernd J. Vorderwülbecke, Alistair Wardrope, Peter Wolf, Elza Márcia Yacubian   +78 more
wiley   +1 more source

Restless legs syndrome is associated with increased risk of migraine

Cephalalgia Reports, 2018
Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to
Maria Didriksen, Thomas F Hansen, Lise W Thørner, Kristoffer S Burgdorf, Christian Erikstrup, Ole B Pedersen, Helene M Paarup, Kaspar R Nielsen, Henrik Hjalgrim, Erik Sørensen, Henrik Ullum   +10 more
doaj   +1 more source

Autism and Migraine: An Unexplored Association?

Brain Sciences, 2020
Autism spectrum disorder is characterized by neurological, psychiatric and medical comorbidities—some conditions co-occur so frequently that comorbidity in autism is the rule rather than the exception.
Luigi Vetri
doaj   +1 more source