Results 91 to 100 of about 181,737 (236)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Migrant workers in the East Midlands labour market 2010 [PDF]
, 2010 This report is an update of previous intelligence (Migrant Workers in the East Midlands Labour Market 2007) on the profile and economic impact of migrant labour in the East Midlands ...
Atfield, G +4 more
core
Voices from the margins: ‘Black’ Caribbean and Mexican heritage women educators in the rural south
, 2005 This paper explores the ways in which immigrant and migrant women educators in the rural South understand and construct narratives of their lives. The ‘Black’ Caribbean and Mexican heritage women educators in this study experience and interpret events ...
Beck, Scott, Gilpin, Lorraine
core +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Pathways to apprenticeships and traineeships for people from culturally and linguistically diverse backgrounds [PDF]
, 2005 Western Australia is experiencing a substantial shortage of skilled labour. The State Government is committed to increasing participation in the workforce across the board, through schemes such as the Plans 4 Jobs, especially because of the current ...
Hastie, B. +4 more
core +1 more source
The economic consequences of ‘brain drain’ of the best and brightest: Microeconomic evidence from five countries [PDF]
, 2010 Brain drain has long been a common concern for migrant-sending countries, particularly for small countries where high-skilled emigration rates are highest.
Gibson, John, McKenzie, David
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Top Ten Problems in the Evidence Base for Public Debate and Policy-Making on Immigration in the UK [PDF]
, 2011 This report sets out the ten most important problems in the evidence base on immigration and migrants in the ...
Carlos Vargas-Silva +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source