Results 101 to 110 of about 1,697,837 (351)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Heat Stress Perception among Native and Migrant Workers in Italian Industries—Case Studies from the Construction and Agricultural Sectors

International Journal of Environmental Research and Public Health, 2019
Climate change will increase the frequency and severity of hazard events such as heat waves, with important effects in several European regions. It is of importance to consider overall effects as well as specific impact on vulnerable population groups ...
A. Messeri, M. Morabito, M. Bonafede, Marcella Bugani, M. Levi, A. Baldasseroni, A. Binazzi, B. Gozzini, S. Orlandini, L. Nybo, A. Marinaccio   +10 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DINAMIKA PROBLEMATIKA SOSIAL PERLINDUNGAN BURUH MIGRAN INDONESIA PASCA REFORMASI DAN RELEVANSINYA DENGAN TANTANGAN WIRAUSAHA DI ERA MASYARAKAT EKONOMI ASEAN (MEA)

Jurnal Kawistara, 2018
The problems of Indonesian migrant workers (TKI), especially Indonesian migrant workers are complex. Weak regulation in favor of migrant workers and regulatory abuses are common.
Raden Muhammad Mihradi, Ferry Muhammadsyah Siregar   +1 more
doaj   +1 more source

Legal Standing of the Organization of Islamic Cooperation for Indonesian Migrant Workers

Indonesian Journal of Advocacy and Legal Services, 2020
This manuscript aims to analyze the extent to which the role, the tendency, the influence of the Organization of Islamic Cooperation (OIC) to protect Indonesian migrant workers in that member states.
Mellisa Towadi, Agustinus Supriyanto
doaj   +1 more source

Migrant workers in Rochdale and Oldham [PDF]

, 2008
This research focuses on the needs and experiences of Central and Eastern European migrants living and working in Rochdale and Oldham. It was commissioned by Oldham Housing Investment Partnership, Oldham Metropolitan Borough Council, Oldham Rochdale ...
Condie, J, Scullion, LC, Steele, A
core   +1 more source

Healthcare financing and social protection policies for migrant workers in Malaysia

PLoS ONE, 2020
Background For Malaysia, a nation highly dependent on migrant labour, the large non-citizen workforce presents a unique health system challenge. Although documented migrant workers are covered by mandatory healthcare insurance (SPIKPA), financial ...
Tharani Loganathan, Zhie X Chan, N. Pocock   +2 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Embracing city life: physical activities and the social integration of the new generation of female migrant workers in urban China

, 2020
Drawing on empirical data from interviews with young Chinese female rural–urban migrant workers in the Pearl River Delta of China’s Guangdong province, this article explores the ways in which physical activities help to fulfil the ‘urban dream’ of this ...
Huan Xiong, A. Bairner, Zhi Tang
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source