Results 151 to 160 of about 4,671,452 (419)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

The relationship between international migration, trade, and development: some paradoxes and findings [PDF]

open access: yes
The interactions among trade, international migration, and economic development in migrant-sending areas are complex, and paradoxes abound. This paper summarizes global trends in world migration and remittances, discusses some paradoxes surrounding the ...
J. Edward Taylor
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Inequality and schooling responses to globalization forces: lessons from history [PDF]

open access: yes
Given the intensity of the current debate about the impact of globalization on brain drain in the Third World and inequality in the First World, it might be useful to look at these forces during the first global century, ending in 1914.
Jeffrey G. Williamson
core  

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Planned relocation in Asia and the Pacific

open access: yesForced Migration Review, 2018
Promising policy developments are underway in Asia and the Pacific to address climate and disaster-related displacement, yet the deeper governance structures required to embed protection are not yet in place, especially for planned relocation.
Jessie Connell, Sabira Coelho
doaj  

Political implications of U.S. public attitudes toward immigration on the immigration policymaking process [PDF]

open access: yes
Three developments in U.S. public attitudes have emerged since the 2001 terrorist attacks. First, Americans have shifted their thinking about the salience or importance of immigration issues.
Valerie F. Hunt
core  

World migration report 2018 [PDF]

open access: yes, 2018
"This volume is the result of a highly collaborative venture involving a multitude of partners and contributors under the direction of the editors. The World Migration Report 2018 project commenced in September 2016 and culminated in the launch of the ...
International Organization for Migration
core  

Interplay of integrins and selectins in metastasis

open access: yesMolecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva   +2 more
wiley   +1 more source

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