Results 41 to 50 of about 33,240 (213)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interregional Migration Flows in Russia: A Network Approach

AlterEconomics
Interregional migration in Russia surpasses both intraregional and international migration in vo-lume, playing a pivotal role in redistributing human capital across the country. To capture migration patterns between regions comprehensively, it is crucial
Andrey V. SMIRNOV
doaj   +1 more source

Les flux migratoires dans l’oblast d’Irkoutsk : orientation et tendances

Bulletin de l’Association de Géographes Français, 2019
This study identifies stable migration flows in Irkutsk district within the national framework of migration flows between different regions of Russian Federation. Some of the flows have been identified as facilitating population growth in Irkutsk Oblast (
Alexandre Sukhodolov, Andrei Atanov, Natalia Kuznetsova, Oxana Chuprova, Tatiana Ozernikova   +4 more
doaj   +1 more source

How inter-state amity and animosity complement migration networks to drive refugee flows: A multi-layer network analysis, 1991-2016.

PLoS ONE, 2021
What drives the formation and evolution of the global refugee flow network over time? Refugee flows in particular are widely explained as the result of pursuits for physical security, with recent research adding geopolitical considerations for why states
Justin Schon, Jeffrey C Johnson
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

MIGRATION MEXICO – UNITED STATES: DIMENSIONS AND PERSPECTIVES

EtnoAntropoZum, 2016
Migration flows in the Americas have expanded in the last decades, especially from Central and South America to North America. The Americas comprise the largest flows of migration worldwide.
Roberto Zepeda, Jorge Virchez, Alfonso Marquina Marquez   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Labour Market Restrictions and Migrations in the EU: a Case of Ukrainian Migration [PDF]

Romanian Journal of European Affairs, 2015
The thesis aims to estimate the future migration flows from Ukraine to the European Union. Based on the experience of previous EU enlargements and econometric modelling using the method of Ordinary Least Squares with fixed effects, multiple forecasts ...
Tomáš Ducháč, Wadim Strielkowsk, Anna Matušková   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source