Results 41 to 50 of about 54,161 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

“Dearest Little Wife”: 'The Gender Work of Polish Transnational Families in Past and Present'

open access: yesNordic Journal of Migration Research, 2018
Drawing on ethnographic fieldwork among circular migrants from present-day Poland to Denmark and by revisiting the classic 'The Polish Peasant in Europe and America' (1918-1920), the article brings together two examples of migration flows: the late 19th ...
Marie Sandberg
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Improving estimates of migration flows to Eurostat [PDF]

open access: yes, 2011
In this paper we identify the current mandatory requirements and issues concerning the supply of detailed migration data to Eurostat. Using simple illustrations on immigration to the United Kingdom, we show how substantial and significant improvements ...
Disney, G.   +6 more
core  

Global Migration Trends in an Era of Globalization [PDF]

open access: yesДемографија, 2016
The author analyzes the impact of globalization on the transformation of international migration flows. The author considers the features of global trends in international migration: growth of international migration, expansion of international migration
Ivan Aleshkovski
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Possibilities of using econometrical methods in studying of interregional interactions of migration in transportation

open access: yesВестник университета
Thе article presents a set of methodological approaches to forecasting the spatial heterogeneity of transportation migration flows in Russia. The purpose of the study is to develop a methodological basis for forecasting the migration flows spatial ...
A. A. Bychkova
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Internal migration in Brazil using circular visualization

open access: yesRegional Studies, Regional Science, 2018
In Brazil – a developing country and one that in its last census in 2010 presented a number of five-year interstate migrations of approximately 4.6 million people – the study of internal migration is a complex exercise given the size and diversity of the
Emerson Augusto Baptista   +2 more
doaj   +1 more source

How inter-state amity and animosity complement migration networks to drive refugee flows: A multi-layer network analysis, 1991-2016.

open access: yesPLoS ONE, 2021
What drives the formation and evolution of the global refugee flow network over time? Refugee flows in particular are widely explained as the result of pursuits for physical security, with recent research adding geopolitical considerations for why states
Justin Schon, Jeffrey C Johnson
doaj   +1 more source

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