Results 51 to 60 of about 88,544 (265)

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

The impact of air travel on the precocity and severity of COVID-19 deaths in sub-national areas across 45 countries

Scientific Reports, 2022
Human travel fed the worldwide spread of COVID-19, but it remains unclear whether the volume of incoming air passengers and the centrality of airports in the global airline network made some regions more vulnerable to earlier and higher mortality.
Ettore Recchi, Alessandro Ferrara, Alejandra Rodriguez Sanchez, Emanuel Deutschmann, Lorenzo Gabrielli, Stefano Iacus, Luca Bastiani, Spyridon Spyratos, Michele Vespe   +8 more
doaj   +1 more source

Attitudes toward immigration in Europe: Cross-regional differences [version 1; peer review: 2 approved]

Open Research Europe, 2023
Background: This article investigates how European public opinion has responded to short-term variations in regional immigration over the past decade (2010-2019). Methods: Combining data from the European Social Survey and the European Union Labour Force
Jérôme Gonnot, Lenka Dražanová
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Migrant Associations: Enhancing Migrant Agency and Advancing Social Justice

Revista Tecnológica
Migrant associations play a crucial role in enhancing migrant agency and advancing social justice by fostering social, economic, and political empowerment.
Victoria Castillo Rueda
doaj   +1 more source

Caseworker Prejudice: Exploring Secondary Non-Take-Up from Below Among Latino Immigrants in Madrid, London, and New York City

Swiss Journal of Sociology, 2021
This article investigates the understudied phenomenon of secondary non-take-up (NTU) among Latino immigrants in Madrid, London, and New York City from their own perspective. It examines the reasons behind secondary NTU across the three sites and examines
Mallet Marie, Garcia Edwin
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Who Needs Them? Care Work, Migration and Public Policy

Cuadernos de Relaciones Laborales, 2012
This paper examines how immigration policies on migrant care workers are both pragmatic ‘policy solutions’ and also reflect and construct social ideas and relations about gender, labour and nation, with a particular focus on the UK.
Bridget Anderson
doaj   +1 more source