Results 61 to 70 of about 1,064,076 (263)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Leisure time as an aspect of quality of life in the population of the Municipality of Gornja Rijeka

open access: yesGeoadria, 2017
The way an individual spends leisure time in his/her environment is one of the factors that influence his/her quality of life Due to the features of space (natural and anthropogenic environment), size and structure of settlement, population, the ...
Monika Šabijan   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Migration and Ageing of the Island Population – Five Stories from Iž

open access: yesMigracijske i etničke teme, 2002
The paper analyses population development on the island of Iž during the period from 1857 to 2001, with special focus on the role that migration has on the ageing of the population. The processes that effected the demographic picture of the island during
Sanja Klempić, Sonja Podgorelec
doaj  

STUDIES IN THE MIGRATION OF LEPIDOPTERA [PDF]

open access: yesTransactions of the Royal Entomological Society of London, 1942
Williams, C. B.   +3 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

When Colour Matters: Policing and Hate Crime

open access: yesSocial Inclusion, 2014
Contrary to the image of Sweden as a tolerant, colour-blind and non-racial country, which is based on the narrative of a country for instance associated with solidarity with the so-called Third World; in this article we argue that racial attributes, e.g.
Berit Wigerfelt   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Connections between Central Asia and Mediaeval Croatia

open access: yesMigracijske i etničke teme, 1999
The paper analyses the development of Croat visions of self-origin, especially in relation to the Central Asian or Central Eurasian world. Located on the southern rim of the Pannonia plain, which constitutes a type of continuity of the great Eurasian ...
Emil Heršak, Sanja Lazanin
doaj  

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