Šišmiši su jedini leteći sisavci, pa kao takvi imaju vrlo specifične prilagodbe. Vrlo su dinamične i pokretljive vrste, a kako bi mogli letjeti, potrebno je bilo izgubiti na masi. Gubitkom mase izgubili su i određen dio genoma. Zbog gubitka dijelova genoma razvijena je mogućnost zaraze patogenima, ali bez upale.
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