Results 31 to 40 of about 856,702 (253)

Realizations of slice hyperholomorphic generalized contractive and positive functions

open access: yes, 2014
We introduce generalized Schur functions and generalized positive functions in setting of slice hyperholomorphic functions and study their realizations in terms of associated reproducing kernel Pontryagin spacesComment: Revised version,to appear in the ...
Alpay, Daniel   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Man, a wide garden: Milan Kundera as a young Stalinist [PDF]

open access: yes, 2007
This article analyses early Stalinist poetry, written by writer Milan Kundera, published in his collection Clovek, zahrada sira (Man, A Wide Garden) in ...
Culik, J.
core  

On one type of compactification of positive integers

open access: yes, 2015
A compact metric ring containing the set of positive integers as dense subset is studied.
Pasteka, Milan
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

AE regularity of interval matrices

open access: yes, 2017
Consider a linear system of equations with interval coefficients, and each interval coefficient is associated with either a universal or an existential quantifier.
Hladík, Milan
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih   +40 more
wiley   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas   +39 more
wiley   +1 more source

L’Opus Dei in Italia durante il pontificato di Pio XII: stato della questione e prospettive di ricerca / Opus Dei in Italy during the pontificate of Pius XII: state of the question and research perspectives [PDF]

open access: yesStudia et Documenta
Overview of the development of Opus Dei in Italy up to 1958. Brief summary of the current state of research and knowledge acquired. Proposal of guidelines for future scientific work.
Cosimo di Fazio, Alfredo Méndiz
doaj   +1 more source

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