Results 91 to 100 of about 124,481 (254)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal‐Organic Frameworks

Advanced Science, EarlyView.
The crystalline structure, the atomic numbers of the constituent elementsand the size of MOF crystals each influence their photoluminescence and scintillation properties in distinct ways. Together, these factors provide valuable guidelines for designing systems with optimized performance and tunable timing characteristics, arising from the synergistic ...
Francesca Cova, Jacopo Perego, Biplab Joarder, Nobuhiro Yanai, Anna Vedda, Silvia Bracco, Angiolina Comotti, Angelo Monguzzi, Irene Villa   +8 more
wiley   +1 more source

Concentration‐Driven Li+ Solvation Engineering with TDMAP‐Based Porphyrin Additives for Dendrite‐Free Li Metal Batteries

Advanced Science, EarlyView.
The electrolyte engineering of introducing tetrakis(4‐N, N‐dimethylaminophenyl)porphyrin (TDMAP) is designed to modulate Li+ solvation structure and solid electrolyte interphase, where the interaction with PF₆− anions is altered (Li+–NMe2–PF₆−). Consequently, the cells with optimal additive concentration achieve high Coulombic efficiency (∼99%), and ...
Pooria Afzali, Jian Wang, Sergio Rodriguez, Jin‐Hyun Chang, Luca Magagnin, Maximilian Fichtner   +5 more
wiley   +1 more source

Gli ospitalieri di S. Giovanni di Gerusalemme a Milano; la domus di S. Croce nei documenti dell’Archivio di Stato di Milano (tra XII e inizi XIV secolo)

Studi di Storia Medioevale e di Diplomatica: Nuova Serie, 2018
Attraverso la documentazione dell'Archivio di Stato di Milano (di cui si dà edizione) l'autore ricostruisce le vicende della domus ospitaliera di Milano, descrivendone articolazione istituzionale e patrimonio fondiario.
Giovanni Garuti
doaj  

Current Collector Engineering for New Efficient Bioresorbable Sodium‐Ion Batteries

Advanced Science, EarlyView.
A bioresorbable Na‐ion battery is proposed with Mo or Mg thin‐film current collectors for temporary implants. Mo‐based batteries exhibit superior electrochemical performance and stable cycling compared with Mg counterparts. XPS was used to investigate the Mo/Mg surface oxidation.
Bincy Lathakumary Vijayan, Eleonora Vandini, Vedi Kuyil Azhagan Muniraj, Hussien Hammoud, Oussama Jamai, Eve Djenizian, Marc Ramuz, Daniela Giuliani, Manuela Zavatti, Yann Tison, Hervé Martinez, Lucas Teolis, Esma Ismailova, David Moreau, Sébastien Maria, Thierry Djenizian   +15 more
wiley   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Two‐Dimensional Quaternary Alloys of (RuMoVNb)Se2 for Superior Hydrogen Evolution Reaction Catalysis

Advanced Science, EarlyView.
Composition‐tuned (RuMoVNb)Se2 quaternary alloy nanosheets are synthesized via colloidal reactions. Incorporation of Ru into (MoVNb)Se2 ternary alloys results in more metallic electronic structures and significantly enhances their electrocatalytic activity for the hydrogen evolution reaction (HER) under alkaline, acidic, and neutral conditions.
Junaid Ihsan, Ju Yeon Kim, Irtiqa Mishal, Jun Hyeok Choi, Jeong Eun An, Youn Jun Choi, Doyeon Kim, In Hye Kwak, Gianvito Vilé, Ik Seon Kwon, Hong Seok Kang, Jeunghee Park   +11 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source