Results 41 to 50 of about 124,737 (256)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Finanziarizzazione e mercati urbani in chiave di low geopolitics: considerazioni sul caso Milano
Geography NotebooksFinancialization and Urban Markets through the Lens of Low Geopolitics: Reflections on the Case of Milan The financialization of real estate has reshaped global financial geographies, clustering investments in major cities following low geopolitics ...
Alberto Bortolotti +1 more
doaj +1 more source
Natural born pedagogy. Approcci filosofici e sperimentali alla pedagogia digitale
Italian Journal of Educational Technology, 2017 Review of the book E. Gola & G. Piredda (2016). Natural born Pedagogy. Approcci filosofici e sperimentali alla pedagogia digitale. Milano, IT: Guerini Scientifica Milano, IT:
Fabrizio Ravicchio
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Brazilian Archives of Biology and Technology, 2010 In this work, the influence of native starter cultures on the microbiological, physicochemical and sensorial characteristics of Milano salami type was studied.
Ângela Maria Fiorentini +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Il contatto linguistico nel medioevo lombardo
Revista de Filología Románica, 2018 La formazione di una koinè si può considerare la caratteristica principale dello sviluppo della lingua lombarda dal Quattrocento al Cinquecento. Fino a che punto Milano influenzasse la koinè lombarda è tuttavia ancora una questione aperta.
Josh Brown
doaj +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source