Results 31 to 40 of about 740,817 (339)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lanx, 2015 Si pubblicano qui le relazioni presentate durante il seminario interdisciplinare e interateneo dal titolo “Milano Archeologia per Expo 2015. Verso una valorizzazione del patrimonio archeologico della città di Milano”.
Daniela Massara, Fabrizio Slavazzi
doaj +1 more source
Transient Flow and Transport Modelling of an Historical CHC Source in North-West Milano
Water, 2019 Legislative Decree 152/2006 requires Public Authorities to identify the subjects who are responsible for soil and groundwater contamination. In highly urbanized areas with a long industrial history and an elevated number of potential contaminant sources,
L. Colombo +3 more
semanticscholar +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Omega Project: Achille and Pier Giacomo Castiglioni’s Last Lesson on Architecture and the City
Histories of Postwar ArchitectureThe Omega Centre represents a remarkable yet largely overlooked achievement by Achille and Pier Giacomo Castiglioni. Situated directly on Milan’s Piazza Duomo, the project distinguished itself amid the contemporary proliferation of shops and showrooms ...
Chiara Monterumisi, Ines Tolic
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih +40 more
wiley +1 more source
Dalla Piazza d’Armi a CityLife: uno spazio in evoluzione a Milano
Geography NotebooksFrom Piazza d’Armi to CityLife: An Evolving Space in Milan One of the most significant and recent examples of the process of reappropriation of abandoned or underused spaces in the city of Milan is the case of the recovery of the former Fiera di Milano ...
Maristella Bergaglio
doaj +1 more source
Il contatto linguistico nel medioevo lombardo
Revista de Filología Románica, 2018 La formazione di una koinè si può considerare la caratteristica principale dello sviluppo della lingua lombarda dal Quattrocento al Cinquecento. Fino a che punto Milano influenzasse la koinè lombarda è tuttavia ancora una questione aperta.
Josh Brown
doaj +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source