Results 271 to 280 of about 772,479 (371)

The Scale of Neurodegeneration in Moderate‐to‐Severe Traumatic Brain Injury: A Systematic Review of Longitudinal Studies

Annals of Neurology, EarlyView.
Synthesis of Literature: Neurodegeneration in Moderate‐Severe TBI. Objective Although moderate‐to‐severe traumatic brain injury (msTBI) was once considered a static neural event following resolution of acute injuries, numerous studies now demonstrate progressive losses to volume and white matter integrity in the months and years postinjury, leading to ...
Bhanu Sharma, Leanne Monteiro, Alana Changoor, Brenda Colella, Robin Green   +4 more
wiley   +1 more source

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Annals of Neurology, EarlyView.
Objective The objective of this study was to evaluate the timing of change of Alzheimer's disease (AD) plasma biomarkers (Aβ42/Aβ40, p‐tau217, p‐tau181, GFAP, and NfL) from six different assay platforms, alongside established AD biomarkers, using amyloid and tau positron emission tomography (PET)‐based AD progression timelines.
Marta Milà‐Alomà, Duygu Tosun, Suzanne E. Schindler, Isabella Hausle, Kellen K. Petersen, Yan Li, Jeffrey L. Dage, Lei Du‐Cuny, Ziad S. Saad, Benjamin Saef, Gallen Triana‐Baltzer, David L. Raunig, Janaky Coomaraswamy, Michael Baratta, Emily A. Meyers, Yulia Mordashova, Carrie E. Rubel, Kyle Ferber, Hartmuth Kolb, Nicholas J. Ashton, Henrik Zetterberg, Erin G. Rosenbaugh, Martin Sabandal, Leslie M. Shaw, Anthony W. Bannon, William Z. Potter, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team   +27 more
wiley   +1 more source

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies

Annals of Neurology, EarlyView.
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat, Rebecca Zack, R. Tyler Skrinak, James F. Morley, Roseanne Davila‐Rivera, Sanaz Arezoumandan, Katherine Dorfman, Kelvin Luk, David A. Wolk, Daniel Weintraub, Thomas F. Tropea, Edward B. Lee, Sharon X. Xie, Ganesh Chandrasekaran, Virginia M.‐Y. Lee, David Irwin, Rizwan S. Akhtar, Alice S. Chen‐Plotkin   +17 more
wiley   +1 more source

Deep Brain Stimulation for VPS16‐Related Dystonia: A Multicenter Study

Annals of Neurology, EarlyView.
Objective The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16‐related dystonia. Methods This observational study collected preoperative and postoperative demographic, clinical, stimulation, genetic, neuroimaging, and neurophysiological data of medically refractory DYT‐VPS16 ...
Tatiana Svorenova, Luigi M. Romito, Ahmet Kaymak, Eoin Mulroy, Laura Cif, Elena Moro, Kirsten E. Zeuner, Simone Zittel, Jan Niklas Petry‐Schmelzer, Doreen Gruber, Liesanne Centen, Alberto Albanese, Miriama Ostrozovicova, Vladimir Han, Veronika Magocova, Kamil Knorovsky, Aurelia Kollova, Barbara Garavaglia, Nico Golfrè‐Andreasi, Chiara Reale, Alberto Mazzoni, Giovanna Zorzi, Roberto Eleopra, Vincenzo Levi, Thomas Foltynie, Patricia Limousin, Harith Akram, Ludvic Zrinzo, Francesca Magrinelli, David Murphy, Henry Houlden, Manju A. Kurian, Claudio Baiata, Steffen Paschen, Katja Lohmann, Jens Volkmann, Wolfgang Hamel, Michael T. Barbe, Martje E. van Egmond, MAJ Tijssen, Lubos Ambro, Veronika Jurkova, Robert Jech, Petra Havrankova, Juliane Winkelmann, Michael Zech, Matej Skorvanek   +46 more
wiley   +1 more source

Mapping Postictal Aphasia through Signal Complexity: A Stereo‐Electroencephalography Study

Annals of Neurology, EarlyView.
Objective The postictal period provides an opportunity to investigate the pathophysiology underlying aphasia and recovery following epileptic seizures. This study examines postictal aphasia in stereo‐electroencephalography (SEEG)‐explored patients to identify brain regions associated with task‐specific language deficits using signal complexity analysis.
Ionuț‐Flavius Bratu, Christian G. Bénar, Samuel Medina Villalon, Lison Ciavatti, Fantine Mazel, Fabrice Bartolomei, Agnès Trébuchon   +6 more
wiley   +1 more source

Prediction of mild cognitive impairment using blood multi-omics data. [PDF]

Front Genet
Zhang DF, Bayrak CS, Zeng Q, Wang M, Zhang B.   +4 more
europepmc   +1 more source

Hospice Care in a Cohort of Elders with Dementia and Mild Cognitive Impairment

, 2005
David B. Bekelman, Betty S. Black, Andrew D. Shore, Judy D. Kasper, Peter V. Rabins   +4 more
openalex   +1 more source

Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline

Annals of Neurology, EarlyView.
Objective To investigate how sex and age at menopause influence the interplay between Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies, and their associations with cognitive decline. Methods We analyzed data from: (1) three Rush Alzheimer's Disease Center cohorts (i.e., the Religious Orders Study, Rush Memory and Aging Project, and
Madeline Wood Alexander, D. Luke Fischer, Lawren VandeVrede, Emma Nichols, Lei Yu, James R. Pike, Walter Swardfager, Che‐Yuan Wu, Mario Masellis, Liisa A. M. Galea, Katherine Zukotynski, Gillian Einstein, Sandra E. Black, Lisa L. Barnes, Julie A. Schneider, Zoe Arvanitakis, Kaitlin B. Casaletto, Jennifer S. Rabin   +17 more
wiley   +1 more source

Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer's Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis. [PDF]

Neuromolecular Med
Serna MF, Mosquera M, García-Perdomo HA.   +2 more
europepmc   +1 more source

Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood‐Based Biomarkers

Annals of Neurology, EarlyView.
Objective Blood‐based biomarkers for Alzheimer's disease (AD), representing antemortem indicators of AD pathophysiology, have greatly improved the accuracy of diagnosis. However, these biomarkers may not capture a frequent coincident pathology, such as cerebrovascular disease.
Tamil Iniyan Gunasekaran, Danurys Sanchez, Dolly Reyes‐Dumeyer, Rabel Ventura, Clarissa Morales, Mohamad Alshikho, Annie J. Lee, Rafael A. Lantigua, Yian Gu, Lawrence S. Honig, Badri N. Vardarajan, Adam M. Brickman, Richard Mayeux   +12 more
wiley   +1 more source