Results 301 to 310 of about 482,563 (349)

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Multimorbidity patterns in dementia and mild cognitive impairment. [PDF]

Front Psychiatry
Valdevila Figueira JA, Valdevila Santiesteban R, Carvajal Parra ID, Benenaula Vargas LP, Ramírez A, Leon-Rojas JE, Rodas JA.   +6 more
europepmc   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Erratum: Patient- and Caregiver-Reported Impact of Symptoms in Alzheimer Disease, Mild Cognitive Impairment, and Dementia. [PDF]

Neurol Clin Pract
Seabury J, Weinstein J, Varma A, Rosero SJ, Engebrecht C, Arky A, Zizzi C, Dilek N, Mathewson A, Salem-Spencer S, Santos EJ, Heatwole CR.   +11 more
europepmc   +1 more source

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts

Glia, EarlyView.
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst, Nina Meesters, Tim S. Heistek, Marjo S. van der Knaap, Huibert D. Mansvelder, Rogier Min   +5 more
wiley   +1 more source

Specific cognitive impairment predicts the neuropsychiatric symptoms in patient with mild cognitive impairment. [PDF]

Aging Clin Exp Res
Pan C, Dong N, Yuan X, Li R, Ma J, Su Y, Wang Q, Tu Z, Zheng J, Li Y.   +9 more
europepmc   +1 more source

Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis.

JAMA Netw Open
Aaronson A, Diaz A, Ashford MT, Jin C, Tank R, Miller MJ, Kang JM, Manjavong M, Landavazo B, Eichenbaum J, Truran D, Camacho MR, Fockler J, Flenniken D, Vannini P, Tomaszewski Farias S, Mackin RS, Weiner MW, Nosheny RL, Alzheimer’s Disease Neuroimaging Initiative.   +19 more
europepmc   +1 more source