Results 141 to 150 of about 405,907 (297)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Approach to overcome the bilirubin interference in the estimation of serum creatinine by Jaffe’s method [PDF]

Al Ameen Journal of Medical Sciences
Introduction: Bilirubin has negative interference on creatinine measurement by routinely used Jaffe’s Kinetic method. Hence this study was conducted to find out a possible solution to the problem of bilirubin interference.
C.N. Shruthi, V. Karishma, A.G. Thivyahprabha   +2 more
doaj  

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

Advanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source

A Reliable Strategy to Unravel the Structure and Composition of Semiconducting Conjugated Donor‐Acceptor Block Copolymers

Advanced Science, EarlyView.
This work proposes a reliable strategy to elucidate the structure and composition of conjugated donor‐acceptor block copolymers. The method, based on NMR analysis, allows to extract key structural information such as the number of heterojunctions (NoH) and the number of blocks (NoB) of the copolymers.
Antoine Curé, Pierre‐Alain Bayle, Lucie Rivet, Yann Kervella, Renaud Demadrille, Cyril Aumaître   +5 more
wiley   +1 more source

Scales, Intervals, and Dissonance: Do Interpretations of Harmonized ACGME Milestone Levels Vary by User Role and Specialty? [PDF]

J Grad Med Educ
Schwartz A, Hobbs K, Schumacher DJ.
europepmc   +1 more source

Superradiance and Broadband Emission Driving Fast Electron Dephasing in Open Quantum Systems

Advanced Science, EarlyView.
We uncover the physical origin of ultrafast electron dephasing in solid‐state high‐harmonic generation by simulating the Lindblad equation for the dissipative Hubbard model. Coexistence of Dicke superradiance and broadband emission is revealed, whose destructive interference shortens the effective scattering time and provides a unified picture of ...
Gimin Bae, Youngjae Kim, Jae Dong Lee
wiley   +1 more source

Factors involved in the improvement of prolonged symptoms in patients with COVID-19 treated with Japanese traditional (Kampo) medicine: A single-center, prospective, observational study. [PDF]

Medicine (Baltimore)
Kawamura T, Kohno J, Kikuchi A, Arita R, Takayama S, Ishii T.   +5 more
europepmc   +1 more source