Results 31 to 40 of about 2,755,037 (365)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Modern weapons and military equipments for issue 1-2017 / Современное вооружение и военное оборудование за но. 1-2017 / Savremeno naoružanje i vojna oprema za broj 1-2017

open access: yesVojnotehnički Glasnik, 2017
Vežba ruskih i srpskih pilota BARS 2016 i Slovensko bratstvo 2016. Pripadnici naših oružanih snaga, a posebno RV i PVO, od iskusnih ruskih pilota, uče nove lekcije o upotrebi savremenih aviona.
Nikola M. Ostojić
doaj   +1 more source

Military Attack [PDF]

open access: yes, 2010
Dbyangs lo tells of the difficult times she faced when the village was attacked by the military in the 1950s.The fifty one audio and nine video files in this collection include: villages’ life stories, circle-dancing songs and performance, local history,
G.yu lha
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

MULHERES NAS FORÇAS ARMADAS: UMA REFLEXÃO TEÓRICA

open access: yesLexCult, 2018
This work intends to undertake a reflection on the construction of military identity in contemporary, investing in theorizing about the current historical moment, marked by transformations making us perceive a crisis in the ...
Claudia Maria Sousa Antunes   +1 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Ben Bohane's portrayal of spirit and war in Melanesia

open access: yesPacific Journalism Review, 2006
As a photojournalist, writer and producer of television documentaries, Ben Bohane has spent the past 12 years posting stories about life on the islands of Melanesia to the Western media—illuminating the struggles and the spirit worlds behind the news ...
Ben Bohane, Bec Dean
doaj   +1 more source

Admission of Deaf Soldiers to the Military: Rethinking the Undifferentiated Soldier Paradigm [PDF]

open access: yes, 2018
Keith Nolan, a deaf man with undergraduate and graduate degrees, asked to be admitted to military training to become a uniformed American soldier. The military said no, and the issue was joined. Nolan’s application presents the Department of Defense (DOD)
Schwartz, Michael
core   +2 more sources

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